Accession	MF_00435
Dates	12-JUL-2001 (Created) 7-JUN-2008 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00435; [distribution of match scores in UniProtKB];[seed alignment for MF_00435]

Identifier

ILVC

Protein name

RecName: Full=Ketol-acid reductoisomerase; EC=1.1.1.86; AltName: Full=Acetohydroxy-acid isomeroreductase; AltName: Full=Alpha-keto-beta-hydroxylacil reductoisomerase;

Gene name

ilvC

CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.

CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.

PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.

PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.

SIMILARITY: Belongs to the ketol-acid reductoisomerase family.

Pfam	PF01450; IlvC; 1;
TIGRFAMs	TIGR00465; ilvC; 1;

Oxidoreductase, Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, NADP.

GO:0004455; Molecular function: ketol-acid reductoisomerase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.

From: ILVC_ECOLI (P05793)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		132		132		Potential		H

Size range:	326-494 amino acids
Related UniRules:	None
Template:	Q57179 (ILVC_CORGL)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACC1, BACCR, BACCZ, BACHK, BIFLO, STRCO, SULSO
Plasmid encoded:	None
Comments:	Two additional divergent sequences in SULSO (SSO1322 and SSO1942) not shown in alignment. Enterobacteria have a large insert not found in other sequences.