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UniProtKB/Swiss-Prot entry Q9YFI6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRD_AERPE
Primary accession number Q9YFI6
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on June 26, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 64)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase
Synonyms EC 1.3.3.1
Dihydroorotate oxidase
DHOdehase
DHODase
DHOD
Gene name
Name: pyrD
OrderedLocusNames: APE_0260.1
From
Aeropyrum pernix [TaxID: 56636] [HAMAP proteome]
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K1;
DOI=10.1093/dnares/6.2.83; PubMed=10382966 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.";
DNA Res. 6:83-101(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000002; BAA79175.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E72784; E72784.
RefSeq NP_147090.2; -.
3D structure databases
HSSP P54322; 1EP3. [HSSP ENTRY / PDB]
ModBase Q9YFI6.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
GO:0006207; Biological process: 'de novo' pyrimidine base biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006222; Biological process: UMP biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00224; -; 1.
PBIL [Tree]
InterPro IPR012135; DHO_DHase_1_2.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00911; DHODEHASE_1; FALSE_NEG.
PS00912; DHODEHASE_2; FALSE_NEG.
Genome annotation databases
GeneID 1445772; -.
GenomeReviews BA000002_GR; APE_0260.1.
KEGG ape:APE_0260.1; -.
NMPDR fig|272557.1.peg.197; -.
Phylogenomic databases
HOGENOM Q9YFI6; -.
Genome annotation databases
CMR Q9YFI6; APE_0260.1.
Other
ProtoNet Q9YFI6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Flavoprotein; FMN; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   306  306     Dihydroorotate dehydrogenase. PRO_0000148406
ACT_SITE   132   132        Nucleophile (By similarity). 
Sequence information
Length: 306 AA [This is the length of the unprocessed precursor] Molecular weight: 32121 Da [This is the MW of the unprocessed precursor] CRC64: B07059307532510D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYSQPELSIS IAGLRLQRPV GNASGILGWE PREARLVEEG GGGFFVAKSV TYQPRKGYPQ 

        70         80         90        100        110        120 
PHLYPVAGGI VNAVGLANPG FREASKMLAQ TVEEASIPVI ASIAGGAPGE WVEMASTLEE 

       130        140        150        160        170        180 
AGVSAVELNL SCPHFAGGGL ELGQDPAAVA SVVSAVASTL RIPVIAKLGY SDRLVDAASK 

       190        200        210        220        230        240 
ALEAGARGLT LINSMRAMKI DVYAKKPVLG NRVGGLSGKP IHPIAVRAVY EVYGETRADI 

       250        260        270        280        290        300 
FAAGGVESWE DAVEFYLAGA KAVQVGAAFI TIGPHVLRSI VEGVRRYLWV EGFRSLQDIV 


GYAHRA
Q9YFI6 in FASTA format

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