NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DSM 20267 / Isolate C2A;
PubMed=10094709 [NCBI, ExPASy, EBI, Israel, Japan]
Rosenstein R., Futter-Bryniok D., Gotz F.;
"The choline-converting pathway in Staphylococcus xylosus C2A: genetic and physiological characterization.";
J. Bacteriol. 181:2273-2278(1999).

Comments

FUNCTION: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity).
CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1 .
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF009415; AAD23901.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q9X2M2.

Ontologies

GO:0008812;	Molecular function: choline dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0050660;	Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0006066;	Biological process: cellular alcohol metabolic process (inferred from electronic annotation from InterPro).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_00750; -; 1.
PBIL [Tree]

InterPro

IPR011533; Choline_dehydrogenase.
IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

TIGRFAMs

TIGR01810; betA; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 560`	`560`	`Choline dehydrogenase.`	`PRO_0000205605`
`NP_BIND`	`6 35`	`30`	`FAD (Probable).`
`ACT_SITE`	`472 472`		`By similarity.`

Sequence information

Length: 560 AA [This is the length of the unprocessed precursor]

Molecular weight: 62384 Da [This is the MW of the unprocessed precursor]

CRC64: 4D8395EED9E584D7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKESYDYIII GGGSAGSVLG GRLSEDVSNN VLVLEAGRSD YPWDLLIQMP AALMYPAGNK 

        70         80         90        100        110        120 
LYDWIYETTP EPHMDGRKVG HARGKVLGGS SSINGMIYQR GNPMDYEKWA KPEGMESWDY 

       130        140        150        160        170        180 
AHCLPYFKRL ETTFGSKKGD PYRGHHGPIK LRRGPADNPL FQAFFDAGVE AGYNKTPDVN 

       190        200        210        220        230        240 
GFRQEGFGPF DSQVHNGRRV SASRAYLHPA MKRKNLEVQT RAFVTKLNFE GNKVTGVTFK 

       250        260        270        280        290        300 
KNGKEHTESA KEVILSGGAI NSPQLLQLSG IGDSEHLRSL GIEPRIHLPG VGENFEDHLE 

       310        320        330        340        350        360 
VYVQHACKQP VSMQPSLNKL KMPFIGLQWI LGRKGAAASN HFEGGGFVRS NDDVDYPNLM 

       370        380        390        400        410        420 
FHFLPIAVRY DGTKAPAAHG YQVHVGPMYS NSRGHLKIKS KDPFEKPEFV FNYLSTEEDK 

       430        440        450        460        470        480 
REWVEAIKVA RNILKQKALD PFNGGEISPG PEVQTDEEII EWVKRDGETA LHPSCSCRMG 

       490        500        510        520        530        540 
PASDEMSVVD PETFKVHGME NLRVVDASVM PRTTNGNIHS PVLMMAERAS DIIRGKKPLD 

       550        560 
PQYIDFYRHG VHDKDAGTVK

Q9X2M2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools