ID   DEOC_THEMA              Reviewed;         248 AA.
AC   Q9X1P5;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-NOV-2008, entry version 67.
DE   RecName: Full=Deoxyribose-phosphate aldolase;
DE            EC=4.1.2.4;
DE   AltName: Full=Phosphodeoxyriboaldolase;
DE            Short=Deoxyriboaldolase;
DE            Short=DERA;
GN   Name=deoC; OrderedLocusNames=TM_1559;
OS   Thermotoga maritima.
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=2336;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
RX   MEDLINE=99287316; PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA   Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA   McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA   Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA   Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA   Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- CATALYTIC ACTIVITY: 2-deoxy-D-ribose 5-phosphate = D-
CC       glyceraldehyde 3-phosphate + acetaldehyde.
CC   -!- PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate
CC       degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-
CC       deoxy-D-ribose 1-phosphate: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the deoC/fbaB aldolase family. DeoC type 1
CC       subfamily.
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DR   EMBL; AE000512; AAD36625.1; -; Genomic_DNA.
DR   PIR; B72240; B72240.
DR   RefSeq; NP_229359.1; -.
DR   PDB; 1O0Y; X-ray; 1.90 A; A/B=1-248.
DR   PDBsum; 1O0Y; -.
DR   GeneID; 897566; -.
DR   GenomeReviews; AE000512_GR; TM_1559.
DR   KEGG; tma:TM1559; -.
DR   NMPDR; fig|243274.1.peg.1543; -.
DR   TIGR; TM_1559; -.
DR   HOGENOM; Q9X1P5; -.
DR   BioCyc; TMAR243274:TM_1559-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0004139; F:deoxyribose-phosphate aldolase activity; IEA:HAMAP.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:HAMAP.
DR   GO; GO:0009264; P:deoxyribonucleotide catabolic process; IEA:InterPro.
DR   HAMAP; MF_00114; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011343; DeoC.
DR   InterPro; IPR002915; DeoC/AroFGH_arch.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR10889; DeoC; 1.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF001357; DeoC; 1.
DR   TIGRFAMs; TIGR00126; deoC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytoplasm; Lyase; Schiff base.
FT   CHAIN         1    248       Deoxyribose-phosphate aldolase.
FT                                /FTId=PRO_0000057280.
FT   ACT_SITE    179    179       Schiff-base intermediate with
FT                                acetaldehyde (By similarity).
FT   ACT_SITE    208    208       By similarity.
FT   HELIX         1     16
FT   STRAND       22     24
FT   HELIX        28     34
FT   STRAND       35     39
FT   HELIX        46     59
FT   STRAND       62     66
FT   HELIX        68     70
FT   HELIX        71     78
FT   STRAND       84     90
FT   TURN         91     93
FT   HELIX        98    111
FT   STRAND      114    119
FT   HELIX       122    126
FT   HELIX       130    143
FT   TURN        144    146
FT   STRAND      147    152
FT   HELIX       155    157
FT   HELIX       160    172
FT   STRAND      176    179
FT   STRAND      183    186
FT   HELIX       191    201
FT   STRAND      205    212
FT   HELIX       216    224
FT   STRAND      228    233
FT   HELIX       235    245
SQ   SEQUENCE   248 AA;  27285 MW;  7236D2ECA2CA1951 CRC64;
     MIEYRIEEAV AKYREFYEFK PVRESAGIED VKSAIEHTNL KPFATPDDIK KLCLEARENR
     FHGVCVNPCY VKLAREELEG TDVKVVTVVG FPLGANETRT KAHEAIFAVE SGADEIDMVI
     NVGMLKAKEW EYVYEDIRSV VESVKGKVVK VIIETCYLDT EEKIAACVIS KLAGAHFVKT
     STGFGTGGAT AEDVHLMKWI VGDEMGVKAS GGIRTFEDAV KMIMYGADRI GTSSGVKIVQ
     GGEERYGG
//