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UniProtKB/Swiss-Prot entry Q9V1R3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_PYRAB
Primary accession number Q9V1R3
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 54)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name
Name: hmgA
OrderedLocusNames: PYRAB03640
ORFNames: PAB2106
From
Pyrococcus abyssi [TaxID: 29292] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GE5 / Orsay;
DOI=10.1046/j.1365-2958.2003.03381.x; PubMed=12622808 [NCBI, ExPASy, EBI, Israel, Japan]
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.";
Mol. Microbiol. 47:1495-1512(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ248284; CAB49286.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G75150; G75150.
RefSeq NP_126055.1; -.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase Q9V1R3.
Enzyme and pathway databases
BioCyc PABY272844:PAB2106-MON; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0004420; Molecular function: hydroxymethylglutaryl-CoA reductase (NADPH) activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0015936; Biological process: coenzyme A metabolic process (inferred from electronic annotation from InterPro).
GO:0008299; Biological process: isoprenoid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; FALSE_NEG.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9V1R3.
ProtoNet Q9V1R3.
Genome annotation databases
GeneID 1495254; -.
GenomeReviews AL096836_GR; PYRAB03640.
KEGG pab:PAB2106; -.
NMPDR fig|272844.1.peg.378; -.
Phylogenomic databases
HOGENOM Q9V1R3; -.
Genome annotation databases
CMR Q9V1R3; PYRAB03640.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   411  411     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114463
ACT_SITE   104   104        Charge relay system (By similarity). 
ACT_SITE   310   310        Charge relay system (By similarity). 
ACT_SITE   406   406        Proton donor (By similarity). 
Sequence information
Length: 411 AA [This is the length of the unprocessed precursor] Molecular weight: 44349 Da [This is the MW of the unprocessed precursor] CRC64: 070BA13A30631B31 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTLNVEDII EKVANGEIKL HQVEKYVNGD KRLATEIRRK ALERKLGISL KHIGHYSIDP 

        70         80         90        100        110        120 
NELIGRNIEN MIGVVQIPMG VAGPLKINGE YAKGEFYIPL ATTEGALVAS VNRGCSALTE 

       130        140        150        160        170        180 
AGGVVTTILD DKMTRAPLIR CPNARRAREV AEWVKENLNY LQEKAVAKVT RHGKLRDVKP 

       190        200        210        220        230        240 
FIVGNNLYLR FEFETGDAMG MNMVTIASEE IMKVIEEEFP DVRYLALSGN LCVDKKPNAV 

       250        260        270        280        290        300 
NFILGRGKTV VAEAIVPREI VEKKLKTTPE LIAEVNYFKN LVGSAQAGSY GFNAHFGNIV 

       310        320        330        340        350        360 
GAIFLATGQD EAQITEGSHG ITIAEVTPEG DLYISITMPS LEIGTVGGGT RVPTQREALS 

       370        380        390        400        410 
IMGVAGGGDP PGVNAKKFAE IVAGAVLAGE LSLLAAIAAK HLARAHKMLG R
Q9V1R3 in FASTA format

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