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UniProtKB/Swiss-Prot entry Q9UYZ2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VORB_PYRAB
Primary accession number Q9UYZ2
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 2001
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name Ketoisovalerate oxidoreductase subunit vorB
Synonyms VOR
EC 1.2.7.7
2-oxoisovalerate oxidoreductase beta chain
2-oxoisovalerate ferredoxin reductase subunit beta
Gene name
Name: vorB
OrderedLocusNames: PYRAB13650
ORFNames: PAB1473
From
Pyrococcus abyssi [TaxID: 29292] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GE5 / Orsay;
DOI=10.1046/j.1365-2958.2003.03381.x; PubMed=12622808 [NCBI, ExPASy, EBI, Israel, Japan]
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.";
Mol. Microbiol. 47:1495-1512(2003).
Comments
  • CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
  • SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma chain (By similarity).
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ248287; CAB50270.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A75047; A75047.
RefSeq NP_127040.1; -.
3D structure databases
HSSP P94692; 1KEK. [HSSP ENTRY / PDB]
ModBase Q9UYZ2.
Enzyme and pathway databases
BioCyc PABY272844:PAB1473-MON; -.
Ontologies
GO
GO:0043807; Molecular function: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity (inferred from electronic annotation from EC).
GO:0030976; Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011766; TPP_enzyme_bd_C.
Graphical view of domain structure.
Pfam PF02775; TPP_enzyme_C; 1.
Pfam graphical view of domain structure.
BLOCKS Q9UYZ2.
ProtoNet Q9UYZ2.
Genome annotation databases
GeneID 1496754; -.
GenomeReviews AL096836_GR; PYRAB13650.
KEGG pab:PAB1473; -.
NMPDR fig|272844.1.peg.1447; -.
Phylogenomic databases
HOGENOM Q9UYZ2; -.
Genome annotation databases
CMR Q9UYZ2; PYRAB13650.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   311  311     Ketoisovalerate oxidoreductase subunit vorB. PRO_0000099956
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 34759 Da [This is the MW of the unprocessed precursor] CRC64: 1EBE2609519DAC30 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEVPEDVKRR LTLPFEENFF AGHTACQGCG ASLGLRYVLK AYGRKTILVI PACCSTIIAG 

        70         80         90        100        110        120 
PWPYSALNAN LFHTAFETTG AVISGIEAAL KALGYKVKGE DGIMVVGWAG DGGTADIGLQ 

       130        140        150        160        170        180 
ALSGFLERGH DALYIMYDNE AYMNTGIQRS SSTPYGAWTT NTPGGKRHFL EKRHKKKVID 

       190        200        210        220        230        240 
IVIAHRIPYA ATASVAYPED FLRKLKKAQK IPGPSFIQLF APCPTGWRAP TDKTIEIARL 

       250        260        270        280        290        300 
AVQTAYFPLF EYENGKYKIN MPNPKKEPKP IEEFLKLQGR FKYMTKEDIE VLQKWVLEEW 

       310 
ERLKKLAEVF G 

Q9UYZ2 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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