FUNCTION: Conodipine-M catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This activity may be supported by the alpha chain. Conodipine-M inhibits the binding of isradipine (a ligand specific for L-type calcium channel) to L-type calcium channels. It is inhibited by linoleoyl amide and MG14.
CATALYTIC ACTIVITY: Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.
COFACTOR: Calcium.
SUBUNIT: Conodipine-M consists of 2 subunits alpha and beta, which may be linked to each other through one or more disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom duct.
MASS SPECTROMETRY: Mass=8571; Method=Electrospray; Range=1-77; Source=PubMed:7876086;.
SIMILARITY: Belongs to the phospholipase A2 family. Highly divergent.

Copyright

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Cross-references

3D structure databases

ModBase

Q9TWL9.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0005509;	Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004623;	Molecular function: phospholipase A2 activity (inferred from electronic annotation from EC).
GO:0016042;	Biological process: lipid catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0009405;	Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
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Family and domain databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Pyrrolidone carboxylic acid; Secreted; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 77`	`77`	`Conodipine-M alpha chain.`	`PRO_0000086866`
`ACT_SITE`	`36 36`		`Potential.`
`MOD_RES`	`1 1`		`Pyrrolidone carboxylic acid.`

Sequence information

Length: 77 AA [This is the length of the unprocessed precursor]

Molecular weight: 8492 Da [This is the MW of the unprocessed precursor]

CRC64: 73861D7587479D8C [This is a checksum on the sequence]

        10         20         30         40         50         60 
QXPSTAELCK INSNACSVPF SXIPCQKXFL AACDRHDTCY HCGKHFGFKQ DDCDDAFFRD 

        70 
MTALCAHGTD DEGXCPX

Q9TWL9 in FASTA format

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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools