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UniProtKB/Swiss-Prot entry Q9SIY8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LAC5_ARATH
Primary accession number Q9SIY8
Secondary accession numbers None
Integrated into Swiss-Prot on April 3, 2007
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name Laccase-5 [Precursor]
Synonyms EC 1.10.3.2
Benzenediol:oxygen oxidoreductase 5
Urishiol oxidase 5
Diphenol oxidase 5
Gene name
Name: LAC5
Synonyms: LAC1
OrderedLocusNames: At2g40370
ORFNames: T3G21.14
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
Gaynor J.J.;
"Molecular cloning, characterization, and expression of a cDNA clone encoding laccase from Arabidopsis thaliana.";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
[3]
TISSUE SPECIFICITY.
DOI=10.1007/s00425-004-1472-6; PubMed=15940465 [NCBI, ExPASy, EBI, Israel, Japan]
McCaig B.C., Meagher R.B., Dean J.F.D.;
"Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana.";
Planta 221:619-636(2005).
[4]
TISSUE SPECIFICITY.
DOI=10.1093/jxb/erl022; PubMed=16804053 [NCBI, ExPASy, EBI, Israel, Japan]
Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.;
"Mutant identification and characterization of the laccase gene family in Arabidopsis.";
J. Exp. Bot. 57:2563-2569(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF506030; AAM77221.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC007020; AAD25671.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F84828; F84828.
RefSeq NP_181568.1; -.
UniGene At.37061
3D structure databases
HSSP P37064; 1AOZ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q9SIY8.
Organism-specific databases
TAIR At2g40370; -.
Gene expression databases
ArrayExpress Q9SIY8; -.
Ontologies
GO
GO:0048046; Cellular component: apoplast (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from InterPro).
GO:0008471; Molecular function: laccase activity (inferred from electronic annotation from EC).
GO:0046274; Biological process: lignin catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
IPR017761; Laccase.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.420; Cupredoxin; 3.
Pfam PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.
PROSITE PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; 1.
BLOCKS Q9SIY8.
ProtoNet Q9SIY8.
Genome annotation databases
GeneID 818630; -.
GenomeReviews CT485783_GR; AT2G40370.
KEGG ath:AT2G40370; -.
NMPDR fig|3702.1.peg.11166; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Apoplast; Complete proteome; Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    25  25     Potential. 
CHAIN   26   580  555     Laccase-5. PRO_0000283633
DOMAIN   34   150  117     Plastocyanin-like 1. 
DOMAIN   160   312  153     Plastocyanin-like 2. 
DOMAIN   428   564  137     Plastocyanin-like 3. 
METAL   84    84        Copper 1; type 2 (By similarity). 
METAL   86    86        Copper 2; type 3 (By similarity). 
METAL   129   129        Copper 2; type 3 (By similarity). 
METAL   131   131        Copper 3; type 3 (By similarity). 
METAL   481   481        Copper 4; type 1 (By similarity). 
METAL   484   484        Copper 1; type 2 (By similarity). 
METAL   486   486        Copper 3; type 3 (By similarity). 
METAL   543   543        Copper 3; type 3 (By similarity). 
METAL   544   544        Copper 4; type 1 (By similarity). 
METAL   545   545        Copper 2; type 3 (By similarity). 
METAL   549   549        Copper 4; type 1 (By similarity). 
CARBOHYD   80    80        N-linked (GlcNAc...) (Potential). 
CARBOHYD   189   189        N-linked (GlcNAc...) (Potential). 
CARBOHYD   300   300        N-linked (GlcNAc...) (Potential). 
CARBOHYD   340   340        N-linked (GlcNAc...) (Potential). 
CARBOHYD   392   392        N-linked (GlcNAc...) (Potential). 
CARBOHYD   402   402        N-linked (GlcNAc...) (Potential). 
CARBOHYD   410   410        N-linked (GlcNAc...) (Potential). 
CARBOHYD   443   443        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 580 AA [This is the length of the unprocessed precursor] Molecular weight: 64133 Da [This is the MW of the unprocessed precursor] CRC64: EFD565D79AD887CE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDVTKSLLCF ISFVAFLLFS SVAEANKAHH HEFIIQATKV KRLCETHNSI TVNGMFPGPM 

        70         80         90        100        110        120 
LVVNNGDTLV VKVINRARYN ITIHWHGVRQ MRTGWADGPE FVTQCPIRPG SSYTYRFTIQ 

       130        140        150        160        170        180 
GQEGTLWWHA HSSWLRATVY GSLLVFPPAG SSYPFTKPHR NVPLLLGEWW DANPVDVLRE 

       190        200        210        220        230        240 
SIRTGGAPNN SDAYTINGQP GDLYKCSSQD TTVVPINVGE TILLRVINSA LNQPLFFTVA 

       250        260        270        280        290        300 
NHKLTVVGAD ASYLKPFTTN VIVLGPGQTT DVLITGDQPP NRYYMAARAY QSAQNAPFGN 

       310        320        330        340        350        360 
TTTTAILQYK SAPCCGVGGG SGTKKGNSFK PIMPILPAYN DTNTVTRFSQ SFRSLRRAEV 

       370        380        390        400        410        420 
PTEIDENLFV TIGLGLNNCP KNFRSRRCQG PNGTRFTASM NNVSFALPSN YSLLQAHHHG 

       430        440        450        460        470        480 
IPGVFTTDFP AKPPVKFDYT GNNISRSLYQ PDRGTKLYKL KYGSRVQIVL QDTGIVTPEN 

       490        500        510        520        530        540 
HPIHLHGYDF YIIAEGFGNF NPKKDTAKFN LEDPPLRNTV GVPVNGWAVI RFIADNPGVW 

       550        560        570        580 
IMHCHLDAHI SWGLAMAFLV ENGNGVLQTI EQPPHDLPVC 

Q9SIY8 in FASTA format

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