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UniProtKB/Swiss-Prot entry Q9QUL6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NSF_RAT
Primary accession number Q9QUL6
Secondary accession numbers None
Integrated into Swiss-Prot on December 12, 2006
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name Vesicle-fusing ATPase
Synonyms EC 3.6.4.6
N-ethylmaleimide-sensitive fusion protein
NEM-sensitive fusion protein
Vesicular-fusion protein NSF
Gene name
Name: Nsf
Synonyms: Erg1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Brain;
Guan Z., Lu L.R., Zheng Z.C., Liu X.Y.;
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
Viswanathan V., Vincent S.R.;
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[3]
 PROTEIN SEQUENCE OF 11-27; 69-87; 170-187; 218-232; 255-266; 316-335; 338-357; 404-413; 435-446; 534-549; 556-566; 595-631 AND 708-725, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Hippocampus, and Spinal cord;
Lubec G., Afjehi-Sadat L., Diao W.;
Submitted (APR-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF142097; AAD39485.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF189019; AAF01051.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_068516.1; -.
UniGene Rn.13345
3D structure databases
HSSP P18708; 1NSF. [HSSP ENTRY / PDB]
SMR Q9QUL6; 1-201, 489-735.
ModBase Q9QUL6.
Protein-protein interaction databases
IntAct Q9QUL6; -.
PTM databases
PhosphoSite Q9QUL6; -.
Organism-specific databases
RGD 621594; Nsf.
Gene expression databases
ArrayExpress Q9QUL6; -.
GermOnline ENSRNOG00000003905; Rattus norvegicus.
Ontologies
GO
GO:0043198; Cellular component: dendritic shaft (inferred from direct assay from UniProtKB).
GO:0014069; Cellular component: postsynaptic density (traceable author statement from UniProtKB).
GO:0016887; Molecular function: ATPase activity (inferred from physical interaction from UniProtKB).
GO:0008022; Molecular function: protein C-terminus binding (inferred from physical interaction from UniProtKB).
GO:0007269; Biological process: neurotransmitter secretion (traceable author statement from UniProtKB).
GO:0006906; Biological process: vesicle fusion (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR003593; AAA+_ATPase_core.
IPR003959; AAA_ATPase_core.
IPR003960; AAA_ATPase_CS.
IPR003338; ATPaseVAT_N.
IPR004201; Cdc48_2.
IPR001984; Peptidase_S16.
Graphical view of domain structure.
Pfam PF00004; AAA; 2.
PF02933; CDC48_2; 1.
PF02359; CDC48_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00830; ENDOLAPTASE.
SMART SM00382; AAA; 2.
SMART graphical view of domain structure.
PROSITE PS00674; AAA; 1.
BLOCKS Q9QUL6.
Genome annotation databases
Ensembl ENSRNOG00000003905; Rattus norvegicus. [Contig view]
GeneID 60355; -.
KEGG rno:60355; -.
Phylogenomic databases
HOVERGEN Q9QUL6; -.
Other
ProtoNet Q9QUL6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cytoplasm; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Protein transport; Repeat; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   744  744     Vesicle-fusing ATPase. PRO_0000263087
NP_BIND   260   267  8     ATP (Potential). 
NP_BIND   543   550  8     ATP (Potential). 
METAL   550   550        Magnesium (By similarity). 
MOD_RES   259   259        Phosphotyrosine (By similarity). 
Sequence information
Length: 744 AA [This is the length of the unprocessed precursor] Molecular weight: 82652 Da [This is the MW of the unprocessed precursor] CRC64: 82978187FC3E0E03 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGRTMQAAR CPTDELSLSN CAVVNEKDYQ SGQHVMVRTS PNHKYIFTLR THPSVVPGCI 

        70         80         90        100        110        120 
AFSLPQRKWA GLSIGQDIEV ALYSFDKAKQ CIGTMTIEID FLQKKNIDSN PYDTDKMAAE 

       130        140        150        160        170        180 
FIQQFNHQAF SVGQQLVFSF NDKLFGLLVK DIEAMDPSIL KGEPASGKRQ KIEVGLVVGN 

       190        200        210        220        230        240 
SQVAFEKAEN SSLNLIGKAK TKENRQSIIN PDWNFEKMGI GGLDKEFSDI FRRAFASRVF 

       250        260        270        280        290        300 
PPEIVEQMGC KHVKGILLYG PPGCGKTLLA RQIGKMLNAR EPKVVNGPEI LNKYVGESEA 

       310        320        330        340        350        360 
NIRKLFADAE EEQRRLGANS GLHIIIFDEI DAICKQRGSM AGSTGVHDTV VNQLLSKIDG 

       370        380        390        400        410        420 
VEQLNNILVI GMTNRPDLID EALLRPGRLE VKMEIGLPDE KGRLQILHIH TARMRGHQLL 

       430        440        450        460        470        480 
SADVDIKELA VETKNFSGAE LEGLVRAAQS TAMNRHIKAS TKVEVDMEKA ESLQVTRGDF 

       490        500        510        520        530        540 
LASLENDIKP AFGTNQEDYA SYIMNGIIKW GDPVTRVLDD GELLVQQTKN SDRTPLVSVL 

       550        560        570        580        590        600 
LEGPPHSGKT ALAAKIAEES NFPFIKICSP DKMIGFSETA KCQAMKKIFD DAYKSQLSCV 

       610        620        630        640        650        660 
VVDDIERLLD YVPIGPRFSN LVLQALLVLL KKAPPQGRKL LIIGTTSRKD VLQEMEMLNA 

       670        680        690        700        710        720 
FSTTIHVPNI ATGEQLLEAL ELLGNFKDKE RTTIAQQVKG KKVWIGIKKL LMLIEMSLQM 

       730        740 
DPEYRVRKFL ALMREEGASP LDFD
Q9QUL6 in FASTA format

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