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UniProtKB/Swiss-Prot entry Q9K6Z2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BACHD
Primary accession number Q9K6Z2
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BH3582
From
Bacillus halodurans [TaxID: 86665] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153;
DOI=10.1093/nar/28.21.4317; PubMed=11058132 [NCBI, ExPASy, EBI, Israel, Japan]
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.";
Nucleic Acids Res. 28:4317-4331(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000004; BAB07301.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F84097; F84097.
RefSeq NP_244449.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q9K6Z2.
Enzyme and pathway databases
BioCyc BHAL272558:BH3582-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q9K6Z2.
ProtoNet Q9K6Z2.
Genome annotation databases
GeneID 893911; -.
GenomeReviews BA000004_GR; BH3582.
KEGG bha:BH3582; -.
NMPDR fig|272558.1.peg.3582; -.
Phylogenomic databases
HOGENOM Q9K6Z2; -.
Genome annotation databases
CMR Q9K6Z2; BH3582.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   424  424     Histidinol dehydrogenase. PRO_0000135726
ACT_SITE   319   319        Proton acceptor (By similarity). 
ACT_SITE   320   320        Proton acceptor (By similarity). 
METAL   251   251        Zinc (By similarity). 
METAL   254   254        Zinc (By similarity). 
METAL   353   353        Zinc (By similarity). 
METAL   412   412        Zinc (By similarity). 
BINDING   121   121        NAD (By similarity). 
BINDING   183   183        NAD (By similarity). 
BINDING   206   206        NAD (By similarity). 
BINDING   229   229        Substrate (By similarity). 
BINDING   251   251        Substrate (By similarity). 
BINDING   254   254        Substrate (By similarity). 
BINDING   320   320        Substrate (By similarity). 
BINDING   353   353        Substrate (By similarity). 
BINDING   407   407        Substrate (By similarity). 
BINDING   412   412        Substrate (By similarity). 
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 45496 Da [This is the MW of the unprocessed precursor] CRC64: 705853FD6ECFAF0A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIVTINDSV SLKRDLDTGT DMQQNAVHSI IAQVREQGDQ ALFTLTKQFD GADLTTLRVQ 

        70         80         90        100        110        120 
QAEIEAAYRE MEEPVLQAIG EAIENIRDFH ERQKRNSWMT TKSDGTILGQ KITPLDSVGL 

       130        140        150        160        170        180 
YVPGGKAAYP SSIMMNVIPA QVAGVQNIVI VSPPQKDGSI PAGVLVTAAE LGVKTILKVG 

       190        200        210        220        230        240 
GAQAIAALAY GTESVPAVDK ITGPGNIYVA LAKRAVFGHV DIDMIAGPSE IVVLADERAN 

       250        260        270        280        290        300 
PRYIAADLLS QAEHDERASA ILVTPSRALA EEVAVEVDQQ LTTLPKREIA AASIRDYGAI 

       310        320        330        340        350        360 
YVTETLEEAV SVVNELAPEH LEILAEEPMS FLGKIRHAGA IFLGPYSSEP VGDYFAGPNH 

       370        380        390        400        410        420 
VLPTNGTARF SSPLNVDDFV KKSSIISYSK AALLENGAKI SALARLEGLE AHARAIDIRL 


EDER
Q9K6Z2 in FASTA format

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