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[1]
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NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INDUCTION, AND FUNCTION.
TISSUE=Ovary;
DOI=10.1042/BJ20021354; PubMed=12519079 [NCBI, ExPASy, EBI, Israel, Japan]
Chang K.N.,
Lee T.C.,
Tam M.F.,
Chen Y.C.,
Lee L.W.,
Lee S.Y.,
Lin P.J.,
Huang R.N.;
"Identification of galectin I and thioredoxin peroxidase II as two arsenic-binding proteins in Chinese hamster ovary cells.";
Biochem. J. 371:495-503(2003).
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- FUNCTION: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity).
- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
- SUBUNIT: Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2 (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome (By similarity).
- INDUCTION: Up-regulated upon exposure to arsenate.
- MISCELLANEOUS: The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin (By similarity).
- MISCELLANEOUS: Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized (By similarity).
- SIMILARITY: Belongs to the ahpC/TSA family.
- SIMILARITY: Contains 1 thioredoxin domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 199 AA [This is the length of the unprocessed precursor] |
Molecular weight: 22263 Da [This is the MW of the unprocessed precursor] |
CRC64: CDA6E8015E1A055E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSSGNAKIGY PAPNFKATAV MPDGQFRDIC LSEYRGKYVV FFFYPLDFTF VCPTEIIAFS
70 80 90 100 110 120
DRAEEFKKLN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK
130 140 150 160 170 180
ADEGISFRGL FIIDDKGILR QITINDLPVG RSVDEILRLV QAFQFTDKHG EVCPAGWKPG
190
SDTIKPDVQK SKEYFSKQK
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Q9JKY1 in FASTA format |
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ExPASy Home page
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