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UniProtKB/Swiss-Prot entry Q9HH07

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNLI_THEFM
Primary accession number Q9HH07
Secondary accession numbers None
Integrated into Swiss-Prot on June 20, 2001
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name DNA ligase
Synonyms EC 6.5.1.1
Polydeoxyribonucleotide synthase [ATP]
Gene name
Name: lig
From
Thermococcus fumicolans [TaxID: 46540] 
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/j.femsle.2004.05.045; PubMed=15251207 [NCBI, ExPASy, EBI, Israel, Japan]
Rolland J.-L., Gueguen Y., Persillon C., Masson J.-M., Dietrich J.;
"Characterization of a thermophilic DNA ligase from the archaeon Thermococcus fumicolans.";
FEMS Microbiol. Lett. 236:267-273(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ133713; CAC21199.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q9HH07; 1-558.
ModBase Q9HH07.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0003910; Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from UniProtKB-KW).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00407; -; 1.
PBIL [Tree]
InterPro IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9HH07.
ProtoNet Q9HH07.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   559  559     DNA ligase. PRO_0000059621
ACT_SITE   249   249        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 559 AA [This is the length of the unprocessed precursor] Molecular weight: 63598 Da [This is the MW of the unprocessed precursor] CRC64: 173DCFF6FC0110BB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKYSELAGLY RRLEKTTLKT LKTRFVADFL KNVPDELLEI VPYLILGKVF PDWDERELGV 

        70         80         90        100        110        120 
GEKLLIKAVS IATGVPEGEI ENSIKDTGDL GESIALAVKK KKQKSFFSQP LTIKRVYDTF 

       130        140        150        160        170        180 
VKVAESQGEG SQDRKMKYLA NLFMDAQPEE AKYIARTVLG TMRTGVAEGI LRDAIAEAFK 

       190        200        210        220        230        240 
VKAELVERAY MLTSDFGYVT KVAKLEGNEG LSKVRIQVGK PVRPMLAQNA ASVKDALLEM 

       250        260        270        280        290        300 
GGEAAFEIKY DGARVQVHKD GDRVVIYSRR LENVTRSIPE IVEAVRSQLR PEKAIVEGEL 

       310        320        330        340        350        360 
VAVGDGGKPR PFQYVLRRFR RKYNIEEMIE RIPLELNLFD VLYVDGESLV DTPFMERRKR 

       370        380        390        400        410        420 
LEEAVEESER IKLAQQLVTK KAEEAEEFYR RALELGHEGL MAKRLDSVYE PGNRGKKWLK 

       430        440        450        460        470        480 
IKPTMEDLDL VIIGAEWGEG RRAHLLGSFL VAAYDQHRGE FVPVGKVGSG FTDEDLAEFT 

       490        500        510        520        530        540 
KMLKPLIVRE EGKYVEIEPR VVIQVTYQEI QKSPKYESGF ALRFPRYVAL REDKSPEEAD 

       550 
TIERISELYG LQERFKAKR
Q9HH07 in FASTA format

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