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UniProtKB/Swiss-Prot entry Q9CGD8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_LACLA
Primary accession number Q9CGD8
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 2001
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 49)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
OrderedLocusNames: LL1159
ORFNames: L0090
From
Lactococcus lactis subsp. lactis (Streptococcus lactis) [TaxID: 1360] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IL1403;
DOI=10.1101/gr.GR-1697R; PubMed=11337471 [NCBI, ExPASy, EBI, Israel, Japan]
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.;
"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.";
Genome Res. 11:731-753(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006348; AAK05257.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G86769; G86769.
RefSeq NP_267315.1; -.
3D structure databases
ModBase Q9CGD8.
Enzyme and pathway databases
BioCyc LLAC272623:L0090-MON; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS Q9CGD8.
Genome annotation databases
GeneID 1114801; -.
GenomeReviews AE005176_GR; LL1159.
KEGG lla:L0090; -.
NMPDR fig|272623.1.peg.1193; -.
Phylogenomic databases
HOGENOM Q9CGD8; -.
Genome annotation databases
CMR Q9CGD8; LL1159.
Other
ProtoNet Q9CGD8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Homoserine dehydrogenase. PRO_0000066696
DOMAIN   350   423  74     ACT. 
NP_BIND   8    15  8     NADP (By similarity). 
ACT_SITE   206   206        Proton donor (Potential). 
BINDING   106   106        NADP (By similarity). 
BINDING   191   191        Substrate (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46921 Da [This is the MW of the unprocessed precursor] CRC64: B99C159FB1BEF21C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVNIAILGF GTVGTGLPTL ISENKEKLSK ILDEEIVISK VLMRDEKAIE KARAQGYQYD 

        70         80         90        100        110        120 
FVLTLEEILA DSEISIVVEL MGRIEPAKTY ITKVIKAGKN VVTANKDLLA VHGTELRALA 

       130        140        150        160        170        180 
EKHHVALYYE AAVAGGIPIL RTLANSFSSD KITHLLGILN GTSNFMMTKM SEEAWTYDQS 

       190        200        210        220        230        240 
LAKAQELGYA ESDPTNDVDG IDASYKLAIL SEFAFGMTLS PDQISKSGLR TIQKTDVEIA 

       250        260        270        280        290        300 
QQFGYVLKLT GEINEVESGI FAEVSPTFLP KSHPLASVNG VMNAVFIESD GIGDSMFYGA 

       310        320        330        340        350        360 
GAGQKPTATS VLADIVRIVK REKDGTIGKS FNEYARPTSL ANPHDIVNKY YFSVETPDST 

       370        380        390        400        410        420 
GQLLRLVELF TSEDVSFEQV LQQKGDGHRA VVVIISHQIN RVQLLAIQDK LKEEVDFKLL 


NYFKVLGD
Q9CGD8 in FASTA format

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