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UniProtKB/Swiss-Prot entry Q9A5B8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_CAUCR
Primary accession number Q9A5B8
Secondary accession numbers None
Integrated into Swiss-Prot on May 27, 2002
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 44)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: CC_2532
From
Caulobacter crescentus (Caulobacter vibrioides) [TaxID: 155892] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 19089 / CB15;
DOI=10.1073/pnas.061029298; PubMed=11259647 [NCBI, ExPASy, EBI, Israel, Japan]
Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
"Complete genome sequence of Caulobacter crescentus.";
Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE005673; AAK24503.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C87563; C87563.
RefSeq NP_421335.1; -.
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q9A5B8.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
Genome annotation databases
GeneID 943950; -.
GenomeReviews AE005673_GR; CC_2532.
KEGG ccr:CC_2532; -.
NMPDR fig|190650.1.peg.2515; -.
TIGR CC_2532; -.
Phylogenomic databases
HOGENOM Q9A5B8; -.
Other
ProtoNet Q9A5B8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Homogentisate 1,2-dioxygenase. PRO_0000220247
METAL   326   326        Iron (By similarity). 
METAL   332   332        Iron (By similarity). 
METAL   362   362        Iron (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46607 Da [This is the MW of the unprocessed precursor] CRC64: B61AE29016AD9C27 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDLRYQTGFG SYFETEAHPG ALPVGRNSPQ KVPFGLYAEQ LSGSAFTAPR HENRRTWLYR 

        70         80         90        100        110        120 
LRPSAGHEAY QPYAQDKLVS AFPGPATPNR LRWSPLEIPA APTDFVDGLV SLAGNADAAT 

       130        140        150        160        170        180 
LGGIAAHVYL VNVSMKNRVF YNADGEMLIV PQMGELTLVT EMGVLKAGPG HIAVIPRGVR 

       190        200        210        220        230        240 
FRVEVEGPAR GYVCENYGAA FRLPELGPIG ANGLANPRDF EAPVAAFEDI DTPTQVIQKF 

       250        260        270        280        290        300 
QGALWAATWD HSPLDVVAWH GNLTPYRYDL SRFNTINTVS YDHPDPSIFT VLTSPSDTPG 

       310        320        330        340        350        360 
TANCDFVIFP PRWMVAEDTF RPPWFHRNVM SEFMGLIHGA YDAKAGGFVP GGASLHNCMS 

       370        380        390        400        410        420 
DHGPDVASHK KATEVVLAPH KIDGTMAFMF ESRWVFRPTH LALESAALQS DYDACWTGFP 


KARLS
Q9A5B8 in FASTA format

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