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UniProtKB/Swiss-Prot entry Q99489


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name OXDD_HUMAN
Primary accession number Q99489
Secondary accession numbers Q5JXM4 Q8N552
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 77)
Name and origin of the protein
Protein name D-aspartate oxidase
Synonyms DASOX
EC 1.4.3.1
DDO
Gene name
Name: DDO
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DDO-1 AND DDO-2).
TISSUE=Brain;
PubMed=9163533 [NCBI, ExPASy, EBI, Israel, Japan]
Setoyama C., Miura R.;
"Structural and functional characterization of the human brain D-aspartate oxidase.";
J. Biochem. 121:798-803(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DDO-1).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
VARIANT [LARGE SCALE ANALYSIS] LEU-136.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D89858; BAA14031.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL050350; CAI42511.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC032786; AAH32786.3; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC5438; JC5438.
JC5439; JC5439.
RefSeq NP_003640.2; -.
NP_004023.2; -.
UniGene Hs.591348
3D structure databases
HSSP P00371; 1AN9. [HSSP ENTRY / PDB]
ModBase Q99489.
Organism-specific databases
GeneCards GC06M110758; -.
H-InvDB HIX0022729; -.
HGNC HGNC:2727; DDO.
GenAtlas DDO.
MIM 124450; gene. [NCBI / EBI]
PharmGKB PA27194; -.
GeneCards Q99489.
Gene expression databases
ArrayExpress Q99489; -.
CleanEx HS_DDO; -.
GermOnline ENSG00000203797; Homo sapiens.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0003884; Molecular function: D-amino-acid oxidase activity (inferred from electronic annotation from InterPro).
GO:0008445; Molecular function: D-aspartate oxidase activity (traceable author statement from UniProtKB).
GO:0006533; Biological process: aspartate catabolic process (traceable author statement from UniProtKB).
GO:0055114; Biological process: oxidation reduction (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006181; D-amino_acid_oxidase_CS.
IPR006076; FAD-dep_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01266; DAO; 1.
Pfam graphical view of domain structure.
PROSITE PS00677; DAO; 1.
Proteomics databases
PRIDE Q99489; -.
Genome annotation databases
Ensembl ENSG00000203797; Homo sapiens. [Contig view]
GeneID 8528; -.
KEGG hsa:8528; -.
Phylogenomic databases
HOVERGEN Q99489; -.
Other
NextBio 31934; -.
SOURCE DDO; Homo sapiens.
ProtoNet Q99489.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; FAD; Flavoprotein; Oxidoreductase; Peroxisome; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   341  341     D-aspartate oxidase. PRO_0000162770
NP_BIND   6    20  15     FAD (Potential). 
MOTIF   339   341  3     Microbody targeting signal (Potential). 
ACT_SITE   223   223        By similarity. 
ACT_SITE   302   302        By similarity. 
VAR_SEQ   95   153        Missing (in isoform DDO-2). VSP_001269
VARIANT   136   136  1     F -> L (in a breast cancer sample; somatic mutation). VAR_036244 
VARIANT   189   189  1     Q -> E (in dbSNP:rs17622 [NCBI]). VAR_014939 
VARIANT   230   230  1     H -> Y (in dbSNP:rs17621 [NCBI]). VAR_014940 
VARIANT   255   255  1     L -> R (in dbSNP:rs17623 [NCBI]). VAR_014941 
Sequence information
Length: 341 AA [This is the length of the unprocessed precursor] Molecular weight: 37535 Da [This is the MW of the unprocessed precursor] CRC64: 8CAE7501FB7F215C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDTARIAVVG AGVVGLSTAV CISKLVPRCS VTIISDKFTP DTTSDVAAGM LIPHTYPDTP 

        70         80         90        100        110        120 
IHTQKQWFRE TFNHLFAIAN SAEAGDAGVH LVSGWQIFQS TPTEEVPFWA DVVLGFRKMT 

       130        140        150        160        170        180 
EAELKKFPQY VFGQAFTTLK CECPAYLPWL EKRIKGSGGW TLTRRIEDLW ELHPSFDIVV 

       190        200        210        220        230        240 
NCSGLGSRQL AGDSKIFPVR GQVLQVQAPW VEHFIRDGSG LTYIYPGTSH VTLGGTRQKG 

       250        260        270        280        290        300 
DWNLSPDAEN SREILSRCCA LEPSLHGACN IREKVGLRPY RPGVRLQTEL LARDGQRLPV 

       310        320        330        340 
VHHYGHGSGG ISVHWGTALE AARLVSECVH ALRTPIPKSN L 

Q99489 in FASTA format

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