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UniProtKB/Swiss-Prot entry Q98Q32

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DYR_MYCPU
Primary accession number Q98Q32
Secondary accession numbers None
Integrated into Swiss-Prot on August 29, 2001
Sequence was last modified on August 29, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 35)
Name and origin of the protein
Protein name Dihydrofolate reductase
Synonym EC 1.5.1.3
Gene name
Name: folA
OrderedLocusNames: MYPU_5370
From
Mycoplasma pulmonis [TaxID: 2107] [HAMAP proteome]
Taxonomy Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=UAB CTIP;
DOI=10.1093/nar/29.10.2145; PubMed=11353084 [NCBI, ExPASy, EBI, Israel, Japan]
Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis.";
Nucleic Acids Res. 29:2145-2153(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL445565; CAC13710.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A90579; A90579.
RefSeq NP_326368.1; -.
3D structure databases
HSSP P00378; 8DFR. [HSSP ENTRY / PDB]
ModBase Q98Q32.
Enzyme and pathway databases
BioCyc MPUL272635:MYPU_5370-MON; -.
Organism-specific databases
MypuList MYPU_5370; -.
Ontologies
GO
GO:0004146; Molecular function: dihydrofolate reductase activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0006545; Biological process: glycine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0009165; Biological process: nucleotide biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012259; DHFR.
IPR001796; DHFR_reg.
Graphical view of domain structure.
PANTHER PTHR11549:SF1; DHFR; 1.
Pfam PF00186; DHFR_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00070; DHFR.
PROSITE PS00075; DHFR_1; 1.
PS51330; DHFR_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 911218; -.
GenomeReviews AL445566_GR; MYPU_5370.
KEGG mpu:MYPU_5370; -.
Phylogenomic databases
HOGENOM Q98Q32; -.
Genome annotation databases
CMR Q98Q32; MYPU_5370.
Other
ProtoNet Q98Q32.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; One-carbon metabolism; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   179  179     Dihydrofolate reductase. PRO_0000186397
DOMAIN   17   179  163     DHFR. 
Sequence information
Length: 179 AA [This is the length of the unprocessed precursor] Molecular weight: 21491 Da [This is the MW of the unprocessed precursor] CRC64: 89F35380370C9D06 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTMNLIQLLK GKWRFKMIIS IWAMTKEGLI GKDNQMPWHI KEEFQHFRRQ TLHKTLIMGK 

        70         80         90        100        110        120 
NTFFSLPKVF DKRKMYVLSH EKDFKIDHPD VEVIYDYKDL LKEYANNDKK DIYVAGGLYV 

       130        140        150        160        170 
YQQLIPLSDI LIVSIVKGSY EGNKYLSVDF SNFVQYKQPE IYDQFSVYYY KKKDQKNSI
Q98Q32 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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NPSA logo NPSA Sequence analysis tools

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