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UniProtKB/Swiss-Prot entry Q97DC6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_CLOAB
Primary accession number Q97DC6
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on October 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 49)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: CA_C3552
From
Clostridium acetobutylicum [TaxID: 1488] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
DOI=10.1128/JB.183.16.4823-4838.2001; PubMed=11466286 [NCBI, ExPASy, EBI, Israel, Japan]
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.";
J. Bacteriol. 183:4823-4838(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001437; AAK81477.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B97336; B97336.
RefSeq NP_350137.1; -.
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
ModBase Q97DC6.
Enzyme and pathway databases
BioCyc CACE272562:CAC3552-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; FALSE_NEG.
Genome annotation databases
GeneID 1119734; -.
GenomeReviews AE001437_GR; CA_C3552.
KEGG cac:CAC3552; -.
NMPDR fig|272562.1.peg.3666; -.
Phylogenomic databases
HOGENOM Q97DC6; -.
Genome annotation databases
CMR Q97DC6; CA_C3552.
Other
ProtoNet Q97DC6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   320  320     L-lactate dehydrogenase 2. PRO_0000168334
NP_BIND   14    42  29     NAD (By similarity). 
ACT_SITE   181   181        Proton acceptor (By similarity). 
BINDING   94    94        Substrate (By similarity). 
BINDING   126   126        NAD or substrate (By similarity). 
BINDING   157   157        Substrate (By similarity). 
BINDING   235   235        Substrate (By similarity). 
Sequence information
Length: 320 AA [This is the length of the unprocessed precursor] Molecular weight: 34845 Da [This is the MW of the unprocessed precursor] CRC64: 24B11585F6AA5247 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNFVKNKLVV VGAGMVGSAV LNSVLSLNLL SEVVIIDIND NKAKGEALDA SHTTSFAYSP 

        70         80         90        100        110        120 
NVKVRAGNYE DCADAQIIVI TAGPSLKPDD KLDRLVLADT NVKVTDSIMK NICKYTKDAI 

       130        140        150        160        170        180 
IIVVTNPVDI ATYYCQNNFD YPKNKIIGTG TLLDTARMRK IIGKKYNVDS KNVHGYVLGE 

       190        200        210        220        230        240 
HGGSSFTSWS DVNIAGIPFN QLNDIFKDHY KVDKDEVDKE VRDSGIEVLK LKGYTSAGIA 

       250        260        270        280        290        300 
MSVSRLVKAM LLNEQSILPV SSTLEGEYGI NDVALSIPCI ITSNGIEKKL EIPLSKDEVE 

       310        320 
KLNKSADNLK SIIKGLNTNK
Q97DC6 in FASTA format

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