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UniProtKB/Swiss-Prot entry Q96VB8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CATA_CANBO
Primary accession number Q96VB8
Secondary accession numbers None
Integrated into Swiss-Prot on April 23, 2003
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 33)
Name and origin of the protein
Protein name Peroxisomal catalase
Synonym EC 1.11.1.6
Gene name
Name: CTA1
From
Candida boidinii (Yeast) [TaxID: 5477] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
STRAIN=S2;
DOI=10.1128/JB.183.21.6372-6383.2001; PubMed=11591682 [NCBI, ExPASy, EBI, Israel, Japan]
Horiguchi H., Yurimoto H., Goh T.K., Nakagawa T., Kato N., Sakai Y.;
"Peroxisomal catalase in the methylotrophic yeast Candida boidinii: transport efficiency and metabolic significance.";
J. Bacteriol. 183:6372-6383(2001).
Comments
  • FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
  • CATALYTIC ACTIVITY: 2 H2O2 = O2 + 2 H2O.
  • COFACTOR: Heme group.
  • SUBCELLULAR LOCATION: Peroxisome. Note=Bimodally distributed between the cytosol and peroxisomes in methanol-grown cells but is localized exclusively in peroxisomes in oleate- and D-alanine-grown cells.
  • SIMILARITY: Belongs to the catalase family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB064338; BAB69893.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P15202; 1A4E. [HSSP ENTRY / PDB]
ModBase Q96VB8.
Protein family/group databases
PeroxiBase 5262; CboiKat01.
Enzyme and pathway databases
BioCyc MetaCyc:MON-13166; -.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0004096; Molecular function: catalase activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0042744; Biological process: hydrogen peroxide catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.
Gene3D G3DSA:2.40.180.10; Catalase_N; 1.
PANTHER PTHR11465; Catalase; 1.
Pfam PF00199; Catalase; 1.
Pfam graphical view of domain structure.
PRINTS PR00067; CATALASE.
ProDom PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.
PS51402; CATALASE_3; 1.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet Q96VB8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase; Peroxisome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   504  504     Peroxisomal catalase. PRO_0000084919
MOTIF   502   504  3     Microbody targeting signal. 
ACT_SITE   63    63        By similarity. 
ACT_SITE   136   136        By similarity. 
METAL   345   345        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 504 AA [This is the length of the unprocessed precursor] Molecular weight: 57095 Da [This is the MW of the unprocessed precursor] CRC64: CCF63C4FA752DC3B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSNPPTYTTS QGCPVSDAFS TQRISGTKIS IKTPVGPLLL QDFKFLDSLA HFDRERIPER 

        70         80         90        100        110        120 
VVHAKGAGAY GVFEVTEDIS DICSAKFLDT VGKKTKIFTR FSTVGGEKGS SDSARDPRGF 

       130        140        150        160        170        180 
ATKFYTEEGN LDLVYNNTPI FFIRDPTKFP HFIHTQKRNP ATNCKDANMF WDYLTNNPES 

       190        200        210        220        230        240 
LHQIMYLFSN RGTPTSYRKM NGYSGHSYKW YNAKGEWVSS VHFISNQGVH NMTDEEAGDL 

       250        260        270        280        290        300 
SGKDPDFQTM DLYKAIEQGD YPSWECYVQT MTLEEAKKQP FSVYDLTKVW PHKDFPLRHF 

       310        320        330        340        350        360 
GKFTLNENAQ NYFAEVEQAA FSPSHTVPGM EPSNDPVLQS RLFSYPDTHR HRLGVNYSQI 

       370        380        390        400        410        420 
PVNCPMRAVF APQIRDGSMM VNGNLGGTPN YAGAYNCPVQ YQAPIKASSK TPEEQYEGET 

       430        440        450        460        470        480 
LSYDWTEVNE YDFYQPGRFW EVLGKTKGEQ EALVHNVANH VSGADEFIQD RVFAYFSKAN 

       490        500 
PVIGDLIRKE VLKKSPRGAS KNKF
Q96VB8 in FASTA format

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