[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. DOI=10.1016/S0167-4781(02)00295-6; PubMed=12031486 [NCBI, ExPASy, EBI, Israel, Japan] Chavan S.S., Tian W., Hsueh K., Jawaheer D., Gregersen P.K., Chu C.C.; "Characterization of the human homolog of the IL-4 induced gene-1 (Fig1)."; Biochim. Biophys. Acta 1576:70-80(2002).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE PROMOTER USAGE, AND SUBCELLULAR LOCATION. DOI=10.1186/1741-7007-3-16; PubMed=16029492 [NCBI, ExPASy, EBI, Israel, Japan] Wiemann S., Kolb-Kokocinski A., Poustka A.; "Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes."; BMC Biol. 3:16-16(2005).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). TISSUE=Spleen; Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.; "The nucleotide sequence of a long cDNA clone isolated from human spleen."; Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan] Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."; Genome Res. 13:2265-2270(2003).
[5]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). TISSUE=Ovary, and PNS; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[6]	PROTEIN SEQUENCE OF 22-36. DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan] Zhang Z., Henzel W.J.; "Signal peptide prediction based on analysis of experimentally verified cleavage sites."; Protein Sci. 13:2819-2824(2004).

Comments

FUNCTION: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBCELLULAR LOCATION: Isoform 1: Lysosome (By similarity).
SUBCELLULAR LOCATION: Isoform 2: Lysosome (By similarity).

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative promoter usage and alternative splicing.

Name	1
Isoform ID	Q96RQ9-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	IL4I1_2
Isoform ID	Q96RQ9-2
Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.
Features which should be applied to build the isoform sequence: VSP_017173.

TISSUE SPECIFICITY: Primarily found in immune tissues (isoform 1).
INDUCTION: By interleukin-4.
SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF293462; AAK73362.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF293463; AAK73363.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ880386; CAI54291.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ880387; CAI54292.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ880388; CAI54293.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK074097; BAB84923.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358933; AAQ89292.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC064378; AAH64378.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC090852; AAH90852.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_690863.1; -.
NP_758962.1; -.

UniGene

Hs.574492

3D structure databases

PDB

2I8H; Model; -; @=30-504.

[ExPASy / RCSB / EBI]

2I8H; -.

PTM databases

Q96RQ9; -.

Organism-specific databases

GeneCards

GC19M055099; -.

H-InvDB

HIX0015349; -.
HIX0080120; -.

HGNC:19094; IL4I1.

609742; gene. [NCBI / EBI]

PharmGKB

PA38795; -.

GeneCards

Q96RQ9.

Gene expression databases

GermOnline

ENSG00000104951; Homo sapiens.

Ontologies

GO:0005764;	Cellular component: lysosome (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0001716;	Molecular function: L-amino-acid oxidase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000759; Adrndx_reductase.
IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00419; ADXRDTASE.
PR00757; AMINEOXDASEF.

Proteomics databases

PRIDE

Q96RQ9; -.

Genome annotation databases

Ensembl

ENSG00000104951; Homo sapiens. [Contig view]

GeneID

259307; -.

KEGG

hsa:259307; -.

Phylogenomic databases

HOVERGEN

Q96RQ9; -.

Other

93149; -.

IL4I1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative promoter usage; Alternative splicing; Direct protein sequencing; FAD; Flavoprotein; Glycoprotein; Lysosome; Oxidoreductase; Polymorphism; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 21`	`21`
`CHAIN`	`22 567`	`546`	`L-amino-acid oxidase.`	`PRO_0000001710`
`NP_BIND`	`115 116`	`2`	`FAD (By similarity).`
`NP_BIND`	`490 493`	`4`	`FAD (By similarity).`
`BINDING`	`89 89`		`FAD (By similarity).`
`BINDING`	`97 97`		`FAD (By similarity).`
`BINDING`	`116 116`		`Substrate (By similarity).`
`BINDING`	`287 287`		`FAD; via amide nitrogen and carbonyl oxygen (By similarity).`
`BINDING`	`398 398`		`Substrate (By similarity).`
`BINDING`	`481 481`		`FAD (By similarity).`
`CARBOHYD`	`54 54`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`134 134`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`220 220`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`559 559`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`36 199`		`By similarity.`
`VAR_SEQ`	`1 5`		`MAPLA -> MGAERAPQRQPCT (in isoform 2).`	`VSP_017173`
`VARIANT`	`501 501`	`1`	`A -> S (in dbSNP:rs2290772 [NCBI]).`	`VAR_048260`
`CONFLICT`	`24 24`		`W -> R (in Ref. 5; AAH64378).`
`CONFLICT`	`114 114`		`A -> T (in Ref. 2; CAI54291/CAI54293).`

Sequence information

Length: 567 AA [This is the length of the unprocessed precursor]

Molecular weight: 62881 Da [This is the MW of the unprocessed precursor]

CRC64: FFF953CB28D22F19 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT WGLNRTLKPQ 

        70         80         90        100        110        120 
RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT YRDQNTGWIG ELGAMRMPSS 

       130        140        150        160        170        180 
HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE 

       190        200        210        220        230        240 
DIYQMALNQA LKDLKALGCR KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY 

       250        260        270        280        290        300 
LSFAEALRAH SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ 

       310        320        330        340        350        360 
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV PATKVFLSFR 

       370        380        390        400        410        420 
RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW SDAAAAFAGL SREEALRLAL 

       430        440        450        460        470        480 
DDVAALHGPV VRQLWDGTGV VKRWAEDQHS QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG 

       490        500        510        520        530        540 
EHTAYPHGWV ETAVKSALRA AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD 

       550        560 
LAKEEGSHPP VQGQLSLQNT THTRTSH

Q96RQ9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools