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UniProtKB/Swiss-Prot entry Q96PF1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGM7_HUMAN
Primary accession number Q96PF1
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2002
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 56)
Name and origin of the protein
Protein name Protein-glutamine gamma-glutamyltransferase Z
Synonyms TGase Z
TGZ
TG(Z)
EC 2.3.2.13
Transglutaminase 7
Gene name
Name: TGM7
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.M102553200; PubMed=11390390 [NCBI, ExPASy, EBI, Israel, Japan]
Grenard P., Bates M.K., Aeschlimann D.;
"Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.";
J. Biol. Chem. 276:33066-33078(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF363393; AAK97573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_443187.1; -.
UniGene Hs.164661
3D structure databases
HSSP Q08188; 1L9M. [HSSP ENTRY / PDB]
ModBase Q96PF1.
PTM databases
PhosphoSite Q96PF1; -.
Organism-specific databases
GeneCards GC15M041355; -.
HGNC HGNC:30790; TGM7.
GenAtlas TGM7.
MIM 606776; gene. [NCBI / EBI]
PharmGKB PA134870048; -.
GeneCards Q96PF1.
Gene expression databases
ArrayExpress Q96PF1; -.
CleanEx HS_TGM7; -.
GermOnline ENSG00000159495; Homo sapiens.
Ontologies
GO
GO:0008415; Molecular function: acyltransferase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003810; Molecular function: protein-glutamine gamma-glutamyltransferase activity (inferred from electronic annotation from InterPro).
GO:0018149; Biological process: peptide cross-linking (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF00927; Transglut_C; 2.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
Proteomics databases
PRIDE Q96PF1; -.
Genome annotation databases
Ensembl ENSG00000159495; Homo sapiens. [Contig view]
GeneID 116179; -.
KEGG hsa:116179; -.
Phylogenomic databases
HOGENOM Q96PF1; -.
HOVERGEN Q96PF1; -.
Other
DrugBank DB00130; L-Glutamine.
NextBio 79821; -.
SOURCE TGM7; Homo sapiens.
ProtoNet Q96PF1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Calcium; Metal-binding; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   710  710     Protein-glutamine gamma-glutamyltransferase Z. PRO_0000213716
ACT_SITE   279   279        By similarity. 
ACT_SITE   338   338        By similarity. 
ACT_SITE   361   361        By similarity. 
METAL   401   401        Calcium (By similarity). 
METAL   403   403        Calcium (By similarity). 
METAL   450   450        Calcium (By similarity). 
METAL   455   455        Calcium (By similarity). 
Sequence information
Length: 710 AA [This is the length of the unprocessed precursor] Molecular weight: 79941 Da [This is the MW of the unprocessed precursor] CRC64: 046C5ED002563909 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP FQSQNDHITF 

        70         80         90        100        110        120 
VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS LQVSLFTPAN AVIGHYTLKI 

       130        140        150        160        170        180 
EISQGQGHSV TYPLGTFILL FNPWSPEDDV YLPSEILLQE YIMRDYGFVY KGHERFITSW 

       190        200        210        220        230        240 
PWNYGQFEED IIDICFEILN KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ 

       250        260        270        280        290        300 
GNWGEDYSKG VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV 

       310        320        330        340        350        360 
SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL 

       370        380        390        400        410        420 
DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV NADEVIWLLG DGQAQEILAH 

       430        440        450        460        470        480 
NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE GSPEERAVFM KASRKMLGPQ RASLPFLDLL 

       490        500        510        520        530        540 
ESGGLRDQPA QLQLHLARIP EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG 

       550        560        570        580        590        600 
GTQKPFWRHT VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL 

       610        620        630        640        650        660 
KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL INGQIAKDLG 

       670        680        690        700        710 
TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK DIFVTVAGAP
Q96PF1 in FASTA format

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