FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

AE008590; AAL02765.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

C97728; C97728.

RefSeq

NP_359864.1; -.

3D structure databases

ModBase

Q92J42.

Enzyme and pathway databases

BioCyc

RCON272944:RC0227-MON; -.

Ontologies

GO:0004591;	Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from electronic annotation from InterPro).
GO:0030976;	Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from InterPro).
GO:0006096;	Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

ProtoNet

Q92J42.

Genome annotation databases

927961; -.

AE006914_GR; RC0227.

rco:RC0227; -.

fig|272944.1.peg.227; -.

Phylogenomic databases

HOGENOM

Q92J42; -.

Genome annotation databases

CMR

Q92J42; RC0227.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 928`	`928`		`2-oxoglutarate dehydrogenase E1 component.`	`PRO_0000162195`

Sequence information

Length: 928 AA [This is the length of the unprocessed precursor]

Molecular weight: 103801 Da [This is the MW of the unprocessed precursor]

CRC64: 4468B7CE1901591D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGEDFKKTGY LFGGNAVFVE ELYKQYLANP ASVDQTWQEF FAGIKDNNTL LNKSTAKIII 

        70         80         90        100        110        120 
PDEIKKESLN NNLSSEDLNS LKAKEMINAY RKHAHYLANL DPLGLELRKT KNDLKLNIET 

       130        140        150        160        170        180 
FGLDSGQLEE NINITDEFVG TWNCKLSELV TKFDKVYTGS IGVEFEQIEN VAGKNWLYNK 

       190        200        210        220        230        240 
LESEVTFSSE DKKTILNDLV EVEGFEQYLH TKFPGAKRFS IEGGDASIVA MSKAIDLSMH 

       250        260        270        280        290        300 
QGVSEIVIGM AHRGRLNTLT KVVGKPYKAV IADFISGSVF PDELNVSGDV KYHLGYSSDR 

       310        320        330        340        350        360 
TLEDKKIHLS LADNPSHLEA VNPIVAGKVR AKQDILGDTK RSKVKAILVH GDAAFCGQGV 

       370        380        390        400        410        420 
VAESLSMSPL AAYDIGGILH FVINNQLGFT ANAADTRASR YSTEFAKIIA APILHVNGDD 

       430        440        450        460        470        480 
IEAVLKATNI AVEYRQKFGK DVVVEIICYR KYGHNEGDEP MYTQGKMYNI IKNKLTPGNI 

       490        500        510        520        530        540 
YANELVKSGV IDNNYFAKLK EEFKAKLDKE YEQAKSYKQE AHFLGGLWQG ISRTRTQATI 

       550        560        570        580        590        600 
TGISKKTLHD LGTKLCEIPK DFAVNPKLVK LFEARKATLT ADQPIDWATA EQLAFASLLA 

       610        620        630        640        650        660 
SGTNIRLTGQ DSGRGTFSHR HSVLHNQIDG TTYIPLNNLS KEQAKYEVAD SNLSEYAVLG 

       670        680        690        700        710        720 
FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSET KWLRMSGLVV LLPHAFEGQG 

       730        740        750        760        770        780 
PEHSSARLER FLQLAAENNM YVTYPTTPAS IFHLLRRQIL DDTRKPLIVM SPKSLLRHKY 

       790        800        810        820        830        840 
AVSKLDELGE NTTFLPVLDE VTKVDTNNIT KVILCSGKVY YDLFEMRGNN SNIAIIRLEQ 

       850        860        870        880        890        900 
LYPFEKKLVA SLLKKYNRTQ EFIWCQEEPK NMGTWCYIVS HLNDALKEAG IKNEFKYVGR 

       910        920 
EESASPAVGS LQVHNKQQEK LLRTALGI

Q92J42 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools