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UniProtKB/Swiss-Prot entry Q92IR7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_RICCN
Primary accession number Q92IR7
Secondary accession numbers None
Integrated into Swiss-Prot on July 11, 2002
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: RC0353
From
Rickettsia conorii [TaxID: 781] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC VR-613 / Malish 7;
DOI=10.1126/science.1061471; PubMed=11557893 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
"Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
Science 293:2093-2098(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE008600; AAL02891.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A97744; A97744.
RefSeq NP_359990.1; -.
3D structure databases
HSSP P39126; 1HQS. [HSSP ENTRY / PDB]
ModBase Q92IR7.
Enzyme and pathway databases
BioCyc RCON272944:RC0353-MON; -.
Ontologies
GO
GO:0004450; Molecular function: isocitrate dehydrogenase (NADP+) activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006097; Biological process: glyoxylate cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001804; IsoCit_IM_DHase.
IPR014273; Isocitrate_DH_bac.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02924; ICDH_alpha; 1.
PROSITE PS00470; IDH_IMDH; 1.
ProtoNet Q92IR7.
Genome annotation databases
GeneID 927516; -.
GenomeReviews AE006914_GR; RC0353.
KEGG rco:RC0353; -.
NMPDR fig|272944.1.peg.353; -.
Phylogenomic databases
HOGENOM Q92IR7; -.
Genome annotation databases
CMR Q92IR7; RC0353.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   483  483     Isocitrate dehydrogenase [NADP]. PRO_0000083556
METAL   208   208        Magnesium or manganese (By similarity). 
METAL   232   232        Magnesium or manganese (By similarity). 
METAL   236   236        Magnesium or manganese (By similarity). 
BINDING   89    89        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   208   208        Substrate (By similarity). 
SITE   128   128  1     Critical for catalysis (By similarity). 
SITE   175   175  1     Critical for catalysis (By similarity). 
MOD_RES   83    83        Phosphoserine (By similarity). 
Sequence information
Length: 483 AA [This is the length of the unprocessed precursor] Molecular weight: 53936 Da [This is the MW of the unprocessed precursor] CRC64: 126975F8A50545A4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY TSGISEESWE 

        70         80         90        100        110        120 
SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP AVSLHPFTRT LHPNLNLTII 

       130        140        150        160        170        180 
RENEEDLYAG IEYRQTHNMY ESMKLISHTG CEKIIRYAFE YAVKNNRKKV MCLSKDNIMK 

       190        200        210        220        230        240 
FSDGVLHKVF NEIAKEYPQI NNAHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIATL 

       310        320        330        340        350        360 
IENAWKKTIE DGVHTADIYN EQSSSKKVGT KEFAEEVTKR LGQLPTKLPK ADYPLIAEKQ 

       370        380        390        400        410        420 
ESNIDYKIDT KEVKKLVGTD IFVNMNVSSA HDIADKINKL DLGNFELKTI SSKGLKLWPR 

       430        440        450        460        470        480 
DTRFETVSDH WCCRFMNKDG TEIKHLDITR LLEALSTANI DFIKVENLFE FDGVAGYSLA 


QGE
Q92IR7 in FASTA format

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