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UniProtKB/Swiss-Prot entry Q92ID5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUOA_RICCN
Primary accession number Q92ID5
Secondary accession numbers None
Integrated into Swiss-Prot on January 23, 2002
Sequence was last modified on January 23, 2002 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit A
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit A
NDH-1 subunit A
Gene name
Name: nuoA
OrderedLocusNames: RC0485
From
Rickettsia conorii [TaxID: 781] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC VR-613 / Malish 7;
DOI=10.1126/science.1061471; PubMed=11557893 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
"Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
Science 293:2093-2098(2001).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
  • SIMILARITY: Belongs to the complex I subunit 3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE008611; AAL03023.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E97760; E97760.
RefSeq NP_360122.1; -.
3D structure databases
ModBase Q92ID5.
Enzyme and pathway databases
BioCyc RCON272944:RC0485-MON; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0008137; Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from InterPro).
GO:0048038; Molecular function: quinone binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006120; Biological process: mitochondrial electron transport, NADH to ubiquinone (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000440; Oxidored_q4.
Graphical view of domain structure.
PANTHER PTHR11058; Oxidored_q4; 1.
Pfam PF00507; Oxidored_q4; 1.
Pfam graphical view of domain structure.
ProtoNet Q92ID5.
Genome annotation databases
GeneID 928710; -.
GenomeReviews AE006914_GR; RC0485.
KEGG rco:RC0485; -.
Phylogenomic databases
HOGENOM Q92ID5; -.
Genome annotation databases
CMR Q92ID5; RC0485.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase; Quinone; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   123  123     NADH-quinone oxidoreductase subunit A. PRO_0000117875
TRANSMEM   11    31  21     Potential. 
TRANSMEM   68    88  21     Potential. 
TRANSMEM   93   113  21     Potential. 
Sequence information
Length: 123 AA [This is the length of the unprocessed precursor] Molecular weight: 14242 Da [This is the MW of the unprocessed precursor] CRC64: 5395664436F056AC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLQNSELLQE YLPIAIFFGI AVLVSGLIMI LPNLLSTKKY NKDKLEPYEC GFEPFSDARS 

        70         80         90        100        110        120 
KFDICFYLVA ILFIIFDLEI AFLVPWAISL NTIGKIGFFS MMFFLFVLII GFIYEWKKGA 


LDW 

Q92ID5 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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