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UniProtKB/Swiss-Prot entry Q921G7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ETFD_MOUSE
Primary accession number Q921G7
Secondary accession numbers Q3U7K2 Q8BK82 Q9DCT9
Integrated into Swiss-Prot on September 13, 2004
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 59)
Name and origin of the protein
Protein name Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial [Precursor]
Synonyms ETF-ubiquinone oxidoreductase
ETF-QO
EC 1.5.5.1
Electron-transferring-flavoprotein dehydrogenase
ETF dehydrogenase
Gene name
Name: Etfdh
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD;
TISSUE=Bone marrow, Kidney, and Thymus;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 212-222, AND MASS SPECTROMETRY.
STRAIN=C57BL/6;
TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[4]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-95; LYS-152; LYS-222 AND LYS-343, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1016/j.molcel.2006.06.026; PubMed=16916647 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.";
Mol. Cell 23:607-618(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK002483; BAB22135.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK075673; BAC35888.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK141684; BAE24798.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK152624; BAE31367.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169686; BAE41304.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012522; AAH12522.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_080070.1; -.
UniGene Mm.28336
3D structure databases
SMR Q921G7; 38-616.
ModBase Q921G7.
PTM databases
PhosphoSite Q921G7; -.
Organism-specific databases
MGI MGI:106100; Etfdh.
Gene expression databases
CleanEx MM_ETFDH; -.
GermOnline ENSMUSG00000027809; Mus musculus.
Ontologies
GO
GO:0017133; Cellular component: mitochondrial electron transfer flavoprotein complex (traceable author statement from MGI).
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR007859; ETFD_OxRdtase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Pfam PF05187; ETF_QO; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00469; PNDRDTASEII.
PROSITE PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q921G7.
ProtoNet Q921G7.
Genome annotation databases
Ensembl ENSMUSG00000027809; Mus musculus. [Contig view]
GeneID 66841; -.
KEGG mmu:66841; -.
Phylogenomic databases
HOGENOM Q921G7; -.
HOVERGEN Q921G7; -.
Other
NextBio 322795; -.
SOURCE Etfdh; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Acetylation; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transmembrane; Transport; Ubiquinone.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    32  32     Mitochondrion (Potential). 
CHAIN   33   616  584     Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial. PRO_0000008662
TRANSMEM   457   477  21     Potential. 
DOMAIN   576   605  30     4Fe-4S ferredoxin-type. 
NP_BIND   70    84  15     FAD (Potential). 
METAL   560   560        Iron-sulfur (4Fe-4S) (Potential). 
METAL   585   585        Iron-sulfur (4Fe-4S) (Potential). 
METAL   588   588        Iron-sulfur (4Fe-4S) (Potential). 
METAL   591   591        Iron-sulfur (4Fe-4S) (Potential). 
MOD_RES   95    95        N6-acetyllysine. 
MOD_RES   152   152        N6-acetyllysine. 
MOD_RES   222   222        N6-acetyllysine. 
MOD_RES   343   343        N6-acetyllysine. 
CONFLICT   342   342        W -> C (in Ref. 1; BAB22135). 
CONFLICT   355   355        G -> W (in Ref. 1; BAC35888). 
Sequence information
Length: 616 AA [This is the length of the unprocessed precursor] Molecular weight: 68091 Da [This is the MW of the unprocessed precursor] CRC64: 1E5C6F85725E3CEE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLVRLTKLSC PAYHWFHALK IKKCLPLCAP RCSSTSAVPQ ITTHYTVHPR EKDKRWEGVN 

        70         80         90        100        110        120 
MERFAEEADV VIVGAGPAGL SAAIRLKQLA AEQGKDIRVC LVEKAAQIGA HTLSGACLDP 

       130        140        150        160        170        180 
AAFKELFPDW KEKGAPLNTP VTEDRFAILT EKHRIPVPIL PGLPMNNHGN YIVRLGHLVS 

       190        200        210        220        230        240 
WMGEQAEALG VEVYPGYAAA EVLYHEDGSV KGIATNDVGI QKDGAPKTTF ERGLELHAKV 

       250        260        270        280        290        300 
TVFAEGCHGH LAKQLYKKFD LRASCDAQTY GIGLKELWII DEKKWKPGRV DHTVGWPLDR 

       310        320        330        340        350        360 
HTYGGSFLYH LNEGEPLVAV GFVVGLDYQN PYLSPFREFQ RWKHHPSIQP TLEGGKRIAY 

       370        380        390        400        410        420 
GARALNEGGL QSIPKLTFPG GLLIGCSPGF MNVPKIKGTH TAMKSGSLAA ESIFKQLTSE 

       430        440        450        460        470        480 
NLQSKTTGLH VTEYEDNLKQ SWVWKELHAV RNIRPSCHGI LGVYGGMIYT GIFYWILRGM 

       490        500        510        520        530        540 
EPWTLKHKGS DSDQLKPAKD CTPIEYPKPD GQISFDLLSS VALSGTNHEH DQPAHLTLKD 

       550        560        570        580        590        600 
DSIPVNRNLS IYDGPEQRFC PAGVYEFVPL EQGDGFRLQI NAQNCVHCKT CDIKDPSQNI 

       610 
NWVVPEGGGG PAYNGM 

Q921G7 in FASTA format

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