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UniProtKB/Swiss-Prot entry Q92104

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP11B_RANCA
Primary accession number Q92104
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name Cytochrome P450 11B, mitochondrial [Precursor]
Synonyms EC 1.14.15.4
CYPXIB
P450C11
Steroid 11-beta-hydroxylase
P-450(11 beta,aldo)
Gene name
Name: CYP11B
From
Rana catesbeiana (Bull frog) [TaxID: 8400] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Aquarana.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Adrenal gland;
PubMed=7744036 [NCBI, ExPASy, EBI, Israel, Japan]
Nonaka Y., Takemori H., Halder S.K., Sun T., Ohta M., Hatano O., Takakusu A., Okamoto M.;
"Frog cytochrome P-450 (11 beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis.";
Eur. J. Biochem. 229:249-256(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D10984; BAA01756.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S69347; S69347.
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase Q92104.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0004507; Molecular function: steroid 11-beta-monooxygenase activity (inferred from electronic annotation from EC).
GO:0006700; Biological process: C21-steroid hormone biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
ProtoNet Q92104.
Phylogenomic databases
HOVERGEN Q92104; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Iron; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Steroidogenesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    45  45     Mitochondrion (Potential). 
CHAIN   46   517  472     Cytochrome P450 11B, mitochondrial. PRO_0000003607
METAL   465   465        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 517 AA [This is the length of the unprocessed precursor] Molecular weight: 59539 Da [This is the MW of the unprocessed precursor] CRC64: 8F94DCD66BA6370B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLEKTAARQI GSCLMRCRTL DTTSPLWTGF SRLSTAPLIH EAREDGSLAS QTLPYEAIPT 

        70         80         90        100        110        120 
TGRSAWFNLF QFWRKNSFQH MHLAMEENFQ NLGPIYREKL GTHNSVNIML PQDVARLFQS 

       130        140        150        160        170        180 
EGIFPRRMTM EAWSKHRELR NHKQGVFLLN GEAWRSDRII LNKEVLSLAG VKKFLPFLDE 

       190        200        210        220        230        240 
AAADFVTFMK KRMSKNTRGS LTVDLYADLF RFTLEASSYV LYGQRLGLLE EHPNADTLRF 

       250        260        270        280        290        300 
ISAVETVLKT TLPLLYYPHQ ILQLFQTRLW NEHMHAWDVI FEQADRCIQN IYQEYCLGQE 

       310        320        330        340        350        360 
RGYSGIMAEL LLQAELPLDS IKANITELMA GGVDTTAMPL LFTLFELARN PSVQRELREE 

       370        380        390        400        410        420 
IRKAEAQNPN DLNQLLNSLP LLKGAIKETL RLYPVGITVQ RHLIKDIVLH NYHIPAGTLV 

       430        440        450        460        470        480 
QVGLYPMGRS PLLFQDALRY DPARWLKRED TNFKALAFGF GSRQCIGRRI AETEITLFLM 

       490        500        510 
HMLKNFQIDT VSKDDIKTVF GFILMPEKPP LLTFRPI
Q92104 in FASTA format

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