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- FUNCTION: Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently five subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
- SUBUNIT: Interacts with the P protein to form the functional polymerase (By similarity).
- SUBCELLULAR LOCATION: Virion. Cytoplasm (By similarity).
- SIMILARITY: Belongs to the rhabdoviridae protein L family.
- SIMILARITY: Contains 1 RdRp catalytic domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 2095 AA [This is the length of the unprocessed precursor] |
Molecular weight: 238192 Da [This is the MW of the unprocessed precursor] |
CRC64: EB43D47D061379AC [This is a checksum on the sequence] |
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10 20 30 40 50 60
MFEWESQDTP SGLPDEESYF PTSKLSVEER MHYLNNVDYN LNSPLISDDI EYLTLKHFGR
70 80 90 100 110 120
AIPSLWKVKN WEIPLEMLKG VGIIKTWDQI HPWMGKWFDS EHNCPQGESF LRTVQAESEL
130 140 150 160 170 180
TSEIPVTFIK GWIGKEIKFP VKRGHHAVHL LMQKVLDLHK LTLLINSVDS GETEKLCESF
190 200 210 220 230 240
GLNSKQSKFE TYSLGTVRYC PGWIFIDKAE ILLDRNFLLM MKDTLIGRLQ TLLSMLGNCE
250 260 270 280 290 300
MEVEQIYTHT ETMLSLYSYG DQIIEKAGNN GYSKIKLLEP ICNLRLSELA HKYRPLVPDF
310 320 330 340 350 360
PHFQEHVETS VREEDTTDGL LSAILSLVNN TEDIQLILTI YGSFRHWGHP FISYFEGLQK
370 380 390 400 410 420
LHDQVTLPKQ IDKEYAAALA SDLAYTVLQR KFSEEKKWYV DSIALSSKHP LKEHVDNGTW
430 440 450 460 470 480
PTAAQIQDFG DRWHLLPLTK CFEVPDLLDP SVIYSDKSHS MNRKEVIDHV ISTPNKPIPS
490 500 510 520 530 540
KKVLETMINN PATDWPTFLK AVDEEGLPRD NLIIGLKGKE RELKIAGRFF SLMSWQLREY
550 560 570 580 590 600
FVITEYLIKT HYVPLFKGLT MADDLTSVVK KMLDNTNGQG LDDYSSICIA NHIDYEKWNN
610 620 630 640 650 660
HQRKESNGPV FRVMGQFLGY PRLFERTHEF FESSLIYYNG RPDLMDVRGD SLVNTTDKMV
670 680 690 700 710 720
CWEGQAGGLE GLRQKGWSVL NLLVINRESS IRNTVVKVLA QGDNQVICTQ YKTKNYKNED
730 740 750 760 770 780
ELKMLLTAMV ENNQTIMNGI ITGTGKLGLI INNDETMQSA DYLNYGKVPV FRGILRGLET
790 800 810 820 830 840
KRWSRVTCIT NDQIPTLAGV MSSVSTNALT VAHFAASPIN AILQYHYFAN FCLMMIAMHN
850 860 870 880 890 900
PAIRSSMYTK MFRKCHIMSK EFKAATLYLD PSLGGVCGIS LARFLIRSFP DPVTEGLAFW
910 920 930 940 950 960
KMIHHNCQSD WLKALSKRCG NPKLARFRPE HIPKIIEDPA ALNISMGMSA SNLLKTEVKG
970 980 990 1000 1010 1020
HLIRTADTIQ NQIIREAAEY LGQEEASLNE FLWDIEPFFP RFLSEFRSST FVGVTDSLIG
1030 1040 1050 1060 1070 1080
LFQNSKTIRG LFKSYYKREL DRLVVKSELS SLEHLGSYRK ETPDSIWECS STQADLLREK
1090 1100 1110 1120 1130 1140
SWGRSVIGMT VPHPLEMFGK GHQKELECIP CQTSGLTYIS SYCPRGINNW YSTVGSLAAY
1150 1160 1170 1180 1190 1200
LGSKTSETTS ILQPWEKDSK IPIIKRATKL RDSISWFVPP DSKLAKSIQQ NLKALTGEDW
1210 1220 1230 1240 1250 1260
EEDIQGFKRT GSALHRFTTS RVSNGGFSAQ SPAKLTRIMT TTDTMRDLGD QNYDFMFQAG
1270 1280 1290 1300 1310 1320
ILYSQMTTGE LRENSTNSTA THYHITCKSC LREIQEPMLE SRIVYNPPSS SRVIKSWIPN
1330 1340 1350 1360 1370 1380
ATEIMEESKP IKLREVDWDP LTRYEKSYHI GRCQGFLYGD LTYQKTGRSE ESSIFPLSIQ
1390 1400 1410 1420 1430 1440
YKVEGSGFMR GFCDGIIRAS AVQALHRRVS SIVSTADVIY GGALYLTNQV GDSPPFQNLC
1450 1460 1470 1480 1490 1500
RSGPLREELE RIPHKMTSSY PTSNSDMGYL IRNYLKRSLK QLSRGRYETK EGPIWVFSDV
1510 1520 1530 1540 1550 1560
RTKKFLGPFS LSTDALNCLY KNKLSKRDKN AVRNLSQLSS RMRSGDLSDE EIGKVEARFS
1570 1580 1590 1600 1610 1620
FTPAEMRHAC KFTIGKTQVP IVMSEWGQEA YGNITMYPVF YSTTKTEKPD WTFSRLQNPT
1630 1640 1650 1660 1670 1680
ISGLRISQQA TGAHYKLRSL LKGMKIHYQD AIGCGDGSGG LSSCLLRENK HCRVIFNSLL
1690 1700 1710 1720 1730 1740
ELTGNTLRGS TPDPPSAING IPQIRDRCVN LNNVWEHPSD LSHPDTWKYF GELKAQFNMD
1750 1760 1770 1780 1790 1800
VDLIVMDMEV QDIDISRRIE QNLRDHVHSL LSRHGTVIYK TYMTIMSENE KSVLDIVGVL
1810 1820 1830 1840 1850 1860
FEDVQLCQTQ YSSSQTSEVY CVMRRLRQKV DSQHVDWQSL VRQGINSKVY CNLPLDKEFE
1870 1880 1890 1900 1910 1920
RALNLYQIDT LVGVPRGLIP NLAVELETLL EIGGLSGGIL GKLVLNIEEG KLGFTMALIV
1930 1940 1950 1960 1970 1980
SCILISESAI CTTRLSNKRE VPSSGACQRM AVCLIGAAIL LSVHHRSIEN HKGAIRMLRH
1990 2000 2010 2020 2030 2040
SVPIRISSKL RKDGKLQSRW SSISREGLAK DVRLNSNMAG VGAWIRVWSR MKDRERRWEA
2050 2060 2070 2080 2090
READSWLKTH NKGLSMEHVR RHTGVLDILH GTGDRLDRSV PTVSSAPRES GTWVE
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Q91DR9 in FASTA format |
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