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UniProtKB/Swiss-Prot entry Q8VHG0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FMO4_MOUSE
Primary accession number Q8VHG0
Secondary accession numbers None
Integrated into Swiss-Prot on October 25, 2005
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    December 16, 2008 (Entry version 43)
Name and origin of the protein
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 4
Synonyms EC 1.14.13.8
Hepatic flavin-containing monooxygenase 4
FMO 4
Dimethylaniline oxidase 4
Gene name
Name: Fmo4
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129/Sv;
TISSUE=Kidney;
Hernandez D., Janmohamed A., Chandan P., Phillips I.R., Shephard E.A.;
"The mouse flavin-containing monooxygenase gene cluster.";
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF461145; AAL66366.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_659127.1; -.
UniGene Mm.155164
3D structure databases
ModBase Q8VHG0.
PTM databases
PhosphoSite Q8VHG0; -.
Organism-specific databases
MGI MGI:2429497; Fmo4.
Gene expression databases
ArrayExpress Q8VHG0; -.
CleanEx MM_FMO4; -.
GermOnline ENSMUSG00000026692; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0031227; Cellular component: intrinsic to endoplasmic reticulum membrane (inferred from electronic annotation from InterPro).
GO:0005792; Cellular component: microsome (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004499; Molecular function: flavin-containing monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012143; dManiline_mOase.
IPR000960; Flavin_mOase.
IPR002256; Flavin_mOase_4.
Graphical view of domain structure.
Pfam PF00743; FMO-like; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000332; FMO; 1.
PRINTS PR00370; FMOXYGENASE.
PR01124; FMOXYGENASE4.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
Proteomics databases
PRIDE Q8VHG0; -.
Genome annotation databases
Ensembl ENSMUSG00000026692; Mus musculus. [Contig view]
GeneID 226564; -.
KEGG mmu:226564; -.
Phylogenomic databases
HOGENOM Q8VHG0; -.
HOVERGEN Q8VHG0; -.
Other
NextBio 378238; -.
SOURCE Fmo4; Mus musculus.
ProtoNet Q8VHG0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   560  559     Dimethylaniline monooxygenase [N-oxide-forming] 4. PRO_0000147661
TRANSMEM   516   530  15     Potential. 
NP_BIND   9    14  6     FAD (Potential). 
NP_BIND   191   196  6     NADP (Potential). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
Sequence information
Length: 560 AA [This is the length of the unprocessed precursor] Molecular weight: 63792 Da [This is the MW of the unprocessed precursor] CRC64: 75C3AEE53693B7AD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG MTRVYRSLVT 

        70         80         90        100        110        120 
NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL LRYIRFKTTV LSVTKRPDFS 

       130        140        150        160        170        180 
ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF LSPHLPLESF PGIHKFKGQI LHSQEYRIPD 

       190        200        210        220        230        240 
AFRGKRILVV GLGNTGGDIA VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN 

       250        260        270        280        290        300 
FLVRVLPSRF INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS 

       310        320        330        340        350        360 
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL YKRVFPPNLE 

       370        380        390        400        410        420 
RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS QKLMAEATKT EQLIKRGVIK 

       430        440        450        460        470        480 
DTSQDKLDFI TYMDELTQCI GAKPSIPLLF IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG 

       490        500        510        520        530        540 
ARNAILTQWD RTLKPLKTRI VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ 

       550        560 
GKLPRRFPPY RLLWYMPQNS
Q8VHG0 in FASTA format

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