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UniProtKB/Swiss-Prot entry Q8PS50

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name THIM_METMA
Primary accession number Q8PS50
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name Hydroxyethylthiazole kinase
Synonyms EC 2.7.1.50
4-methyl-5-beta-hydroxyethylthiazole kinase
Thz kinase
TH kinase
Gene name
Name: thiM
OrderedLocusNames: MM_3234
From
Methanosarcina mazei (Methanosarcina frisia) [TaxID: 2209] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE008384; AAM32930.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_635258.1; -.
3D structure databases
HSSP P39593; 1EKQ. [HSSP ENTRY / PDB]
ModBase Q8PS50.
Enzyme and pathway databases
BioCyc MMAZ192952:MM3234-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004417; Molecular function: hydroxyethylthiazole kinase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009228; Biological process: thiamin biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00228; -; 1.
PBIL [Tree]
InterPro IPR000417; Hyethyz_kinase.
IPR011144; Hyethyz_kinsmonf.
Graphical view of domain structure.
PANTHER PTHR20857:SF14; Hyethyz_kinase; 1.
Pfam PF02110; HK; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000513; Thz_kinase; 1.
PRINTS PR01099; HYETHTZKNASE.
TIGRFAMs TIGR00694; thiM; 1.
Genome annotation databases
GeneID 1481576; -.
GenomeReviews AE008384_GR; MM_3234.
KEGG mma:MM_3234; -.
NMPDR fig|192952.1.peg.3234; -.
Phylogenomic databases
HOGENOM Q8PS50; -.
Genome annotation databases
CMR Q8PS50; MM_3234.
Other
ProtoNet Q8PS50.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Thiamine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   261  261     Hydroxyethylthiazole kinase. PRO_0000156969
METAL   89    89        Magnesium 1 (By similarity). 
METAL   121   121        Magnesium 1 (By similarity). 
BINDING   40    40        Substrate; via amide nitrogen (By similarity). 
BINDING   116   116        ATP (By similarity). 
BINDING   162   162        ATP (By similarity). 
BINDING   189   189        Substrate; via amide nitrogen (By similarity). 
Sequence information
Length: 261 AA [This is the length of the unprocessed precursor] Molecular weight: 27555 Da [This is the MW of the unprocessed precursor] CRC64: 5D5128BAEECBC3EC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKNPLKTIRE TKPLVHHITN WVTIYDCANI TRAFGALPVM AHAPEECADM TGISSALVLN 

        70         80         90        100        110        120 
IGTLTSEIID SMLLSAAAAN KKKIPVVLDA VGVGATRFRD EMAAKILGSV RVDIIKGNYS 

       130        140        150        160        170        180 
EIAKLAGENA ETKGVESTSI SADPQKVAKE FAKSSSSVVV MTGKEDVISD GNRTFVVKNG 

       190        200        210        220        230        240 
HELMGSIVGT GCMAASIIGS FASVNPDYCD AAKDALCYFG AAGELAAKNS AGPGSFKVNL 

       250        260 
YDEVFNLSDE KVQAMMKVEE L
Q8PS50 in FASTA format

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