ID   BETB_XANAC              Reviewed;         490 AA.
AC   Q8PPG7;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   04-NOV-2008, entry version 40.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=XAC0719;
OS   Xanthomonas axonopodis pv. citri (Citrus canker).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=92829;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=306;
RX   MEDLINE=22022145; PubMed=12024217; DOI=10.1038/417459a;
RA   da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA   Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A.,
RA   Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C.,
RA   Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F.,
RA   Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R.,
RA   El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C.,
RA   Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A.,
RA   Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F.,
RA   Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M.,
RA   Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H.,
RA   Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R.,
RA   Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F.,
RA   Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D.,
RA   Trindade dos Santos M., Truffi D., Tsai S.M., White F.F.,
RA   Setubal J.C., Kitajima J.P.;
RT   "Comparison of the genomes of two Xanthomonas pathogens with differing
RT   host specificities.";
RL   Nature 417:459-463(2002).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AE011702; AAM35608.1; -; Genomic_DNA.
DR   RefSeq; NP_641072.1; -.
DR   HSSP; P56533; 1A4S.
DR   GeneID; 1154790; -.
DR   GenomeReviews; AE008923_GR; XAC0719.
DR   KEGG; xac:XAC0719; -.
DR   NMPDR; fig|190486.1.peg.716; -.
DR   HOGENOM; Q8PPG7; -.
DR   BioCyc; XAXO190486:XAC0719-MON; -.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR011264; Betaine_Ald_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    490       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056558.
FT   NP_BIND     229    234       NAD (By similarity).
FT   ACT_SITE    252    252       By similarity.
FT   ACT_SITE    286    286       By similarity.
SQ   SEQUENCE   490 AA;  52381 MW;  856F2EF716305179 CRC64;
     MPRFPDQLLY IGGRYVPARG GHTLEVVNPA TGEVLANVHN AGVDDLDAAV DSAKAGQQRW
     AALTTVERSR ILLRAVALLR ERNDALAQLE TLNTGKPLSE TRSVDVVTGA DVLEYYAGVA
     QALQGAQVPL REGSFFYTRH EPLGVVGAIG AWNYPIQIAL WKAAPALAAG NAMIFKPSEV
     TPLTALKLAE IFTEAGLPDG VFNVLPGDGA SVGTALTEHP QIEKISFTGG TATGRKVMAS
     ASSSSLKEVT MELGGKSPLI VCADADLDVA ADIAMMANFY SSGQVCTNGT RVFVPRALRH
     AFEARLLARV QRIHIGDPLD ERTTFGPLAS AAHMQRVLEH IEQGKAEGAR LLCGGERLQD
     GALVQGYYVA PTIFSDCTDV MTIVREEIFG PVLSLLTYDD EDEAVTRANA TTYGLAAGVV
     TPDLARAHRL IHRLEAGICW VNTWGESPAP MPVGGYKQSG VGRENGLATL QAYTRTKSVQ
     IELERYASVF
//