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UniProtKB/Swiss-Prot entry Q8PMI8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPMT_XANAC
Primary accession number Q8PMI8
Secondary accession numbers None
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 35)
Name and origin of the protein
Protein name Thiopurine S-methyltransferase
Synonyms EC 2.1.1.67
Thiopurine methyltransferase
Gene name
Name: tpm
OrderedLocusNames: XAC1439
From
Xanthomonas axonopodis pv. citri (Citrus canker) [TaxID: 92829] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xanthomonas.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=306;
DOI=10.1038/417459a; PubMed=12024217 [NCBI, ExPASy, EBI, Israel, Japan]
da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities.";
Nature 417:459-463(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE011776; AAM36310.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_641774.1; -.
3D structure databases
HSSP O86262; 1PJZ. [HSSP ENTRY / PDB]
ModBase Q8PMI8.
Enzyme and pathway databases
BioCyc XAXO190486:XAC1439-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008119; Molecular function: thiopurine S-methyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00812; -; 1.
PBIL [Tree]
InterPro IPR008854; Thiopurine_S-MeTrfase.
IPR016822; Thiopurine_S-MeTrfase_sub.
Graphical view of domain structure.
Pfam PF05724; TPMT; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF023956; Thiopurine_S-methyltransferase; 1.
Genome annotation databases
GeneID 1155510; -.
GenomeReviews AE008923_GR; XAC1439.
KEGG xac:XAC1439; -.
NMPDR fig|190486.1.peg.1418; -.
Phylogenomic databases
HOGENOM Q8PMI8; -.
Genome annotation databases
CMR Q8PMI8; XAC1439.
Other
ProtoNet Q8PMI8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   218  218     Thiopurine S-methyltransferase. PRO_0000220138
BINDING   10    10        S-adenosyl-L-methionine (By similarity). 
BINDING   45    45        S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). 
BINDING   66    66        S-adenosyl-L-methionine (By similarity). 
BINDING   123   123        S-adenosyl-L-methionine (By similarity). 
Sequence information
Length: 218 AA [This is the length of the unprocessed precursor] Molecular weight: 24607 Da [This is the MW of the unprocessed precursor] CRC64: E42AF9AC12211124 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDTNFWLERW QLGHTGFHQQ EVLPLLQKHW HALDLPKESR VLVPLCGKTL DMHWLASQGH 

        70         80         90        100        110        120 
RVLGVELSPL AVTQFFDEAG LQPQRHTSAA GEHFIAGPIE IICGDAFALD ASVLADCTAV 

       130        140        150        160        170        180 
YDRAALVALP AELRQRYLQT VYVQLPTHCR GLLITLEYPQ AEKAGPPFSV DATHVHALFD 

       190        200        210 
AAWQVDQLER RDILDQEPRF RDEGVTGLST AVYRLQRR 

Q8PMI8 in FASTA format

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