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UniProtKB/Swiss-Prot entry Q8PAT3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPMT_XANCP
Primary accession number Q8PAT3
Secondary accession numbers None
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 33)
Name and origin of the protein
Protein name Thiopurine S-methyltransferase
Synonyms EC 2.1.1.67
Thiopurine methyltransferase
Gene name
Name: tpm
OrderedLocusNames: XCC1394
From
Xanthomonas campestris pv. campestris [TaxID: 340] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xanthomonas.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 33913 / NCPPB 528 / LMG 568;
DOI=10.1038/417459a; PubMed=12024217 [NCBI, ExPASy, EBI, Israel, Japan]
da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities.";
Nature 417:459-463(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE012239; AAM40692.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_636768.1; -.
3D structure databases
HSSP O86262; 1PJZ. [HSSP ENTRY / PDB]
ModBase Q8PAT3.
Enzyme and pathway databases
BioCyc XCAM190485:XCC1394-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008119; Molecular function: thiopurine S-methyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00812; -; 1.
PBIL [Tree]
InterPro IPR008854; Thiopurine_S-MeTrfase.
IPR016822; Thiopurine_S-MeTrfase_sub.
Graphical view of domain structure.
Pfam PF05724; TPMT; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF023956; Thiopurine_S-methyltransferase; 1.
Genome annotation databases
GeneID 1001811; -.
GenomeReviews AE008922_GR; XCC1394.
KEGG xcc:XCC1394; -.
Phylogenomic databases
HOGENOM Q8PAT3; -.
Genome annotation databases
CMR Q8PAT3; XCC1394.
Other
ProtoNet Q8PAT3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   218  218     Thiopurine S-methyltransferase. PRO_0000220139
BINDING   10    10        S-adenosyl-L-methionine (By similarity). 
BINDING   45    45        S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). 
BINDING   66    66        S-adenosyl-L-methionine (By similarity). 
BINDING   123   123        S-adenosyl-L-methionine (By similarity). 
Sequence information
Length: 218 AA [This is the length of the unprocessed precursor] Molecular weight: 24228 Da [This is the MW of the unprocessed precursor] CRC64: 887F06E595ABF197 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDTDFWLQRW QDGQTGFHQD EVMPLLQKHW PALQLPAHAR VLVPLCGKTL DLHWLAAQGH 

        70         80         90        100        110        120 
RVLGVEISPL AVTQFFDDAG LQPQRHTSRA GEHCIAGPIE IICGDAFTLD ASVLGDCTAV 

       130        140        150        160        170        180 
YDRAALVALP AALRQRYLET VYARLPAGCR GLLITLDYPQ AEKAGPPFSV DAAEVHALFG 

       190        200        210 
TQWKVQELEH RDILDQEPRF RADGVTALST GVYRLQRD 

Q8PAT3 in FASTA format

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