NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(02)08713-5; PubMed=12044378 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
"Genome and virulence determinants of high virulence community-acquired MRSA.";
Lancet 359:1819-1827(2002).

Comments

FUNCTION: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
CATALYTIC ACTIVITY: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
PATHWAY: Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via DXP pathway; isopentenyl-PP from 1-deoxy-D-xylulose 5-phosphate: step 2/6 .
SIMILARITY: Belongs to the ispD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000033; BAB94092.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_645042.1; -.

3D structure databases

ModBase

Q8NYI0.

Enzyme and pathway databases

BioCyc

SAUR196620:MW0227-MON; -.

Ontologies

GO:0050518;	Molecular function: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0016114;	Biological process: terpenoid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00108; -; 1.
PBIL [Tree]

InterPro

IPR001228; ISPD_synthase.
Graphical view of domain structure.

Pfam

PF01128; IspD; 1.
Pfam graphical view of domain structure.

PROSITE

PS01295; ISPD; 1.

Genome annotation databases

GeneID

1004980; -.

GenomeReviews

BA000033_GR; MW0227.

KEGG

sam:MW0227; -.

Phylogenomic databases

HOGENOM

Q8NYI0; -.

Genome annotation databases

CMR

Q8NYI0; MW0227.

Other

ProtoNet

Q8NYI0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Isoprene biosynthesis; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 238`	`238`	`2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1.`	`PRO_0000075623`
`SITE`	`14 14`	`1`	`Transition state stabilizer (By similarity).`
`SITE`	`22 22`	`1`	`Transition state stabilizer (By similarity).`
`SITE`	`160 160`	`1`	`Positions MEP for the nucleophilic attack (By similarity).`
`SITE`	`217 217`	`1`	`Positions MEP for the nucleophilic attack (By similarity).`

Sequence information

Length: 238 AA [This is the length of the unprocessed precursor]

Molecular weight: 26627 Da [This is the MW of the unprocessed precursor]

CRC64: F21440DA33D18AA7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MIYAGILAGG IGSRMGNVPL PKQFLDIDNK PILIHTIEKF ILVSEFNEII IATPAQWISH 

        70         80         90        100        110        120 
TQDILKKYNI TDQRVKVVAG GTDRNETIMN IIDYIRNVNG INNDDVIVTH DAVRPFLTQR 

       130        140        150        160        170        180 
IIKENIEVAE KYGAVDTVIE AIDTIVMSKD KQNIHSIPVR NEMYQGQTPQ SFNIKLLQDS 

       190        200        210        220        230 
YRALSSAQKE ILSDACKIIV ESGHPVKLVR GELYNIKVTT PYDLKVANAI IQGDIADD

Q8NYI0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools