NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(02)08713-5; PubMed=12044378 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
"Genome and virulence determinants of high virulence community-acquired MRSA.";
Lancet 359:1819-1827(2002).

Comments

CATALYTIC ACTIVITY: (S)-malate + acceptor = oxaloacetate + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SIMILARITY: Belongs to the MQO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000033; BAB96391.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_647343.1; -.

3D structure databases

ModBase

Q8NUM4.

Enzyme and pathway databases

BioCyc

SAUR196620:MW2526-MON; -.

Ontologies

GO:0008924;	Molecular function: malate dehydrogenase (acceptor) activity (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099;	Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00212; -; 1.
PBIL [Tree]

InterPro

IPR006231; Malate_quinone_OxRdtase.
Graphical view of domain structure.

Pfam

PF06039; Mqo; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01320; mal_quin_oxido; 1.

ProtoNet

Q8NUM4.

Genome annotation databases

GeneID

1004662; -.

GenomeReviews

BA000033_GR; MW2526.

KEGG

sam:MW2526; -.

Phylogenomic databases

HOGENOM

Q8NUM4; -.

Genome annotation databases

CMR

Q8NUM4; MW2526.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 498`	`498`		`Probable malate:quinone oxidoreductase 2.`	`PRO_0000128748`

Sequence information

Length: 498 AA [This is the length of the unprocessed precursor]

Molecular weight: 55927 Da [This is the MW of the unprocessed precursor]

CRC64: CBD1BE7D253213FF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAKSNSKDIV LIGAGVLSTT FGSMLKEIEP DWNIHVYERL DRPAIESSNE RNNAGTGHAA 

        70         80         90        100        110        120 
LCELNYTVLQ PDGSIDIEKA KVINEEFEIS KQFWGHLVKS GSIENPRGFI NPLPHISYVR 

       130        140        150        160        170        180 
GKNNVKFLKD RYEAMKAFPM FDNIEYTEDI EVMKKWIPLM MKGREDNPGI MAASKIDEGT 

       190        200        210        220        230        240 
DVNFGELTRK MAKSIEAHPN ATVQFNHEVV DFEQLSNGQW EVTVKNRLTG EKFKQVTDYV 

       250        260        270        280        290        300 
FIGAGGGAIP LLQKTGIPES KHLGGFPISG QFLACTNPQV IEQHDAKVYG KEPPGTPPMT 

       310        320        330        340        350        360 
VPHLDTRYID GQRTLLFGPF ANVGPKFLKN GSNLDLFKSV KTYNITTLLA AAVKNLPLIK 

       370        380        390        400        410        420 
YSFDQVIMTK EGCMNHLRTF YPEARNEDWQ LYTAGKRVQV IKDTPEHGKG FIQFGTEVVN 

       430        440        450        460        470        480 
SQDHTVIALL GESPGASTSV SVALEVLERN FPEYKTEWAP KIKKMIPSYG ESLIEDEKLM 

       490 
RKIRKQTSKD LELGYYEN

Q8NUM4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools