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UniProtKB/Swiss-Prot entry Q8NSC4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SAHH_CORGL
Primary accession number Q8NSC4
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 42)
Name and origin of the protein
Protein name Adenosylhomocysteinase
Synonyms EC 3.3.1.1
S-adenosyl-L-homocysteine hydrolase
AdoHcyase
Gene name
Name: ahcY
Synonyms: sahH
OrderedLocusNames: Cgl0752, cg0860
From
Corynebacterium glutamicum (Brevibacterium flavum) [TaxID: 1718] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
Nakagawa S.;
"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
DOI=10.1016/S0168-1656(03)00154-8; PubMed=12948626 [NCBI, ExPASy, EBI, Israel, Japan]
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.";
J. Biotechnol. 104:5-25(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000036; BAB98145.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX927150; CAF19456.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_599981.1; -.
YP_225042.1; -.
3D structure databases
HSSP P10760; 1B3R. [HSSP ENTRY / PDB]
ModBase Q8NSC4.
Enzyme and pathway databases
BioCyc CGLU196627-1:CG0860-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004013; Molecular function: adenosylhomocysteinase activity (inferred from electronic annotation from HAMAP).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00563; -; 1.
PBIL [Tree]
InterPro IPR000043; Ad_hcy_hydrolase.
IPR015878; Ado_hCys_hydrolase_NAD-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
PANTHER PTHR23420; Ad_hcy_hydrolase; 1.
Pfam PF05221; AdoHcyase; 1.
PF00670; AdoHcyase_NAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001109; Ad_hcy_hydrolase; 1.
TIGRFAMs TIGR00936; ahcY; 1.
PROSITE PS00738; ADOHCYASE_1; 1.
PS00739; ADOHCYASE_2; 1.
Genome annotation databases
GeneID 1018748; -.
3343536; -.
GenomeReviews BA000036_GR; Cgl0752.
BX927147_GR; cg0860.
KEGG cgb:cg0860; -.
cgl:NCgl0719; -.
Phylogenomic databases
HOGENOM Q8NSC4; -.
Genome annotation databases
CMR Q8NSC4; Cgl0752.
Other
ProtoNet Q8NSC4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   474  474     Adenosylhomocysteinase. PRO_0000116960
REGION   224   392  169     NAD binding (By similarity). 
BINDING   53    53        Substrate (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   197   197        Substrate (By similarity). 
BINDING   227   227        Substrate (By similarity). 
BINDING   231   231        Substrate (By similarity). 
Sequence information
Length: 474 AA [This is the length of the unprocessed precursor] Molecular weight: 51996 Da [This is the MW of the unprocessed precursor] CRC64: 74673F92624C4F9D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDFKVADLSL AEAGRHQIRL AEYEMPGLMQ LRKEFADEQP LKGARIAGSI HMTVQTAVLI 

        70         80         90        100        110        120 
ETLTALGAEV RWASCNIFST QDEAAAAIVV GSGTVEEPAG VPVFAWKGES LEEYWWCINQ 

       130        140        150        160        170        180 
IFSWGDELPN MILDDGGDAT MAVIRGREYE QAGLVPPAEA NDSDEYIAFL GMLREVLAAE 

       190        200        210        220        230        240 
PGKWGKIAEA VKGVTEETTT GVHRLYHFAE EGVLPFPAMN VNDAVTKSKF DNKYGTRHSL 

       250        260        270        280        290        300 
IDGINRATDM LMGGKNVLVC GYGDVGKGCA EAFDGQGARV KVTEADPINA LQALMDGYSV 

       310        320        330        340        350        360 
VTVDEAIEDA DIVITATGNK DIISFEQMLK MKDHALLGNI GHFDNEIDMH SLLHRDDVTR 

       370        380        390        400        410        420 
TTIKPQVDEF TFSTGRSIIV LSEGRLLNLG NATGHPSFVM SNSFADQTIA QIELFQNEGQ 

       430        440        450        460        470 
YENEVYRLPK VLDEKVARIH VEALGGQLTE LTKEQAEYIG VDVAGPFKPE HYRY
Q8NSC4 in FASTA format

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