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UniProtKB/Swiss-Prot entry Q8NQH0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name THIM_CORGL
Primary accession number Q8NQH0
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 46)
Name and origin of the protein
Protein name Hydroxyethylthiazole kinase
Synonyms EC 2.7.1.50
4-methyl-5-beta-hydroxyethylthiazole kinase
Thz kinase
TH kinase
Gene name
Name: thiM
OrderedLocusNames: Cgl1464, cg1655
From
Corynebacterium glutamicum (Brevibacterium flavum) [TaxID: 1718] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
Nakagawa S.;
"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
DOI=10.1016/S0168-1656(03)00154-8; PubMed=12948626 [NCBI, ExPASy, EBI, Israel, Japan]
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.";
J. Biotechnol. 104:5-25(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000036; BAB98857.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX927152; CAF21473.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_600681.1; -.
YP_225749.1; -.
3D structure databases
HSSP P39593; 1EKQ. [HSSP ENTRY / PDB]
ModBase Q8NQH0.
Enzyme and pathway databases
BioCyc CGLU196627-1:CG1655-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004417; Molecular function: hydroxyethylthiazole kinase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009228; Biological process: thiamin biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00228; -; 1.
PBIL [Tree]
InterPro IPR000417; Hyethyz_kinase.
IPR011144; Hyethyz_kinsmonf.
Graphical view of domain structure.
PANTHER PTHR20857:SF14; Hyethyz_kinase; 1.
Pfam PF02110; HK; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000513; Thz_kinase; 1.
PRINTS PR01099; HYETHTZKNASE.
Genome annotation databases
GeneID 1019438; -.
3342857; -.
GenomeReviews BA000036_GR; Cgl1464.
BX927147_GR; cg1655.
KEGG cgb:cg1655; -.
cgl:NCgl1408; -.
Phylogenomic databases
HOGENOM Q8NQH0; -.
Genome annotation databases
CMR Q8NQH0; Cgl1464.
Other
ProtoNet Q8NQH0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Thiamine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   268  268     Hydroxyethylthiazole kinase. PRO_0000156932
METAL   93    93        Magnesium 1 (By similarity). 
METAL   124   124        Magnesium 1 (By similarity). 
BINDING   44    44        Substrate; via amide nitrogen (By similarity). 
BINDING   119   119        ATP (By similarity). 
BINDING   165   165        ATP (By similarity). 
BINDING   192   192        Substrate; via amide nitrogen (By similarity). 
Sequence information
Length: 268 AA [This is the length of the unprocessed precursor] Molecular weight: 26911 Da [This is the MW of the unprocessed precursor] CRC64: 0019CC83C9D954E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MANSFLDSLT LVRQNTPLVQ CLTNSVVMQF TANVLLAAGA TPAMVDTPAE SAEFAAVANG 

        70         80         90        100        110        120 
VLINAGTPSA EQYQGMTKAI EGARKAGTPW VLDPVAVGGL SERTKYAEGI VDKQPAAIRG 

       130        140        150        160        170        180 
NASEVVALAG LGAGGRGVDA TDSVEVALEA AQLLAKRTGG VVAVSGAEDL IVSADRVTWL 

       190        200        210        220        230        240 
RSGDPMLQLV IGTGCSLGAL TAAYLGATVD SDISAHDAVL AAHAHVGAAG QIAAQKASAP 

       250        260 
GSFAVAFIDA LYDVDAQAVA SLVDVREA
Q8NQH0 in FASTA format

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