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UniProtKB/Swiss-Prot entry Q8NFD2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ANKK1_HUMAN
Primary accession number Q8NFD2
Secondary accession numbers None
Integrated into Swiss-Prot on January 24, 2006
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 47)
Name and origin of the protein
Protein name Ankyrin repeat and protein kinase domain-containing protein 1
Synonyms EC 2.7.11.1
Protein kinase PKK2
X-kinase
Sugen kinase 288
SgK288
Gene name
Name: ANKK1
Synonyms: PKK2, SGK288
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1002/humu.20039; PubMed=15146457 [NCBI, ExPASy, EBI, Israel, Japan]
Neville M.J., Johnstone E.C., Walton R.T.;
"Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1.";
Hum. Mutat. 23:540-545(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Inohara N.;
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND VARIANT LYS-713.
DOI=10.1016/S0920-9964(03)00220-2; PubMed=14741327 [NCBI, ExPASy, EBI, Israel, Japan]
Dubertret C., Gouya L., Hanoun N., Deybach J.-C., Ades J., Hamon M., Gorwood P.;
"The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia.";
Schizophr. Res. 67:75-85(2004).
[4]
IDENTIFICATION.
DOI=10.1126/science.1075762; PubMed=12471243 [NCBI, ExPASy, EBI, Israel, Japan]
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.;
"The protein kinase complement of the human genome.";
Science 298:1912-1934(2002).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-694, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[6]
VARIANTS [LARGE SCALE ANALYSIS] TYR-4; HIS-122; THR-239; LEU-276; ARG-318; THR-347; PHE-366; GLN-367; LYS-376; LYS-426; ARG-442; ARG-451; ARG-490; ILE-595; LEU-596; SER-653; GLY-670; LYS-713; LEU-717; LEU-736 AND LYS-764.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ541797; CAD62569.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF487542; AAQ09005.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF525298; AAM91924.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_848605.1; -.
UniGene Hs.448473
3D structure databases
HSSP Q60778; 1OY3. [HSSP ENTRY / PDB]
ModBase Q8NFD2.
PTM databases
PhosphoSite Q8NFD2; -.
Organism-specific databases
GeneCards GC11P112763; -.
HGNC HGNC:21027; ANKK1.
GenAtlas ANKK1.
HPA HPA012813; -.
MIM 608774; gene. [NCBI / EBI]
PharmGKB PA134872551; -.
GeneCards Q8NFD2.
Gene expression databases
ArrayExpress Q8NFD2; -.
CleanEx HS_ANKK1; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from InterPro).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002110; ANK.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.20; ANK; 2.
Pfam PF00023; Ank; 11.
PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
PRINTS PR01415; ANKYRIN.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00248; ANK; 11.
SMART graphical view of domain structure.
PROSITE PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 11.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8NFD2; -.
Genome annotation databases
Ensembl ENSG00000170209; Homo sapiens. [Contig view]
GeneID 255239; -.
KEGG hsa:255239; -.
Phylogenomic databases
HOGENOM Q8NFD2; -.
HOVERGEN Q8NFD2; -.
Other
NextBio 92527; -.
SOURCE ANKK1; Homo sapiens.
ProtoNet Q8NFD2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ANK repeat; ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Repeat; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   765  765     Ankyrin repeat and protein kinase domain-containing protein 1. PRO_0000085620
DOMAIN   22   289  268     Protein kinase. 
REPEAT   361   390  30     ANK 1. 
REPEAT   394   423  30     ANK 2. 
REPEAT   427   456  30     ANK 3. 
REPEAT   460   489  30     ANK 4. 
REPEAT   493   522  30     ANK 5. 
REPEAT   526   555  30     ANK 6. 
REPEAT   559   588  30     ANK 7. 
REPEAT   592   621  30     ANK 8. 
REPEAT   625   654  30     ANK 9. 
REPEAT   658   687  30     ANK 10. 
REPEAT   691   720  30     ANK 11. 
REPEAT   724   753  30     ANK 12. 
NP_BIND   28    36  9     ATP (By similarity). 
ACT_SITE   145   145        Proton acceptor (By similarity). 
BINDING   51    51        ATP (By similarity). 
MOD_RES   694   694        Phosphothreonine. 
VARIANT   4     4  1     D -> Y (in dbSNP:rs35657708 [NCBI]). VAR_040359 
VARIANT   122   122  1     R -> H (in dbSNP:rs35877321 [NCBI]). VAR_040360 
VARIANT   239   239  1     A -> T (in dbSNP:rs7118900 [NCBI]). VAR_036784 
VARIANT   276   276  1     P -> L (in dbSNP:rs35488601 [NCBI]). VAR_040361 
VARIANT   318   318  1     G -> R (in dbSNP:rs11604671 [NCBI]). VAR_036785 
VARIANT   347   347  1     K -> T (in a breast infiltrating ductal carcinoma sample; somatic mutation). VAR_040362 
VARIANT   366   366  1     L -> F (in dbSNP:rs56339158 [NCBI]). VAR_040363 
VARIANT   367   367  1     H -> Q (in dbSNP:rs34298987 [NCBI]). VAR_040364 
VARIANT   376   376  1     E -> K (in dbSNP:rs56299709 [NCBI]). VAR_040365 
VARIANT   426   426  1     E -> K (in dbSNP:rs55699907 [NCBI]). VAR_040366 
VARIANT   442   442  1     G -> R (in dbSNP:rs4938016 [NCBI]). VAR_036786 
VARIANT   451   451  1     G -> R (in dbSNP:rs34983219 [NCBI]). VAR_040367 
VARIANT   490   490  1     H -> R (in dbSNP:rs2734849 [NCBI]). VAR_036787 
VARIANT   595   595  1     T -> I (in dbSNP:rs55787008 [NCBI]). VAR_040368 
VARIANT   596   596  1     P -> L (in dbSNP:rs7104979 [NCBI]). VAR_040369 
VARIANT   653   653  1     N -> S (in dbSNP:rs55849504 [NCBI]). VAR_040370 
VARIANT   670   670  1     S -> G (in dbSNP:rs56006094 [NCBI]). VAR_040371 
VARIANT   713   713  1     E -> K (in dbSNP:rs1800497 [NCBI]). VAR_025010 
VARIANT   717   717  1     Q -> L (in a lung large cell carcinoma sample; somatic mutation). VAR_040372 
VARIANT   736   736  1     R -> L (in a lung squamous cell carcinoma sample; somatic mutation). VAR_040373 
VARIANT   764   764  1     E -> K (in a lung neuroendocrine carcinoma sample; somatic mutation). VAR_040374 
Sequence information
Length: 765 AA [This is the length of the unprocessed precursor] Molecular weight: 84632 Da [This is the MW of the unprocessed precursor] CRC64: 549F6161B2976BF5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAADPTELRL GSLPVFTRDD FEGDWRLVAS GGFSQVFQAR HRRWRTEYAI KCAPCLPPDA 

        70         80         90        100        110        120 
ASSDVNYLIE EAAKMKKIKF QHIVSIYGVC KQPLGIVMEF MANGSLEKVL STHSLCWKLR 

       130        140        150        160        170        180 
FRIIHETSLA MNFLHSIKPP LLHLDLKPGN ILLDSNMHVK ISDFGLSKWM EQSTRMQYIE 

       190        200        210        220        230        240 
RSALRGMLSY IPPEMFLESN KAPGPKYDVY SFAIVIWELL TQKKPYSGFN MMMIIIRVAA 

       250        260        270        280        290        300 
GMRPSLQPVS DQWPSEAQQM VDLMKRCWDQ DPKKRPCFLD ITIETDILLS LLQSRVAVPE 

       310        320        330        340        350        360 
SKALARKVSC KLSLRQPGEV NEDISQELMD SDSGNYLKRA LQLSDRKNLV PRDEELCIYE 

       370        380        390        400        410        420 
NKVTPLHFLV AQGSVEQVRL LLAHEVDVDC QTASGYTPLL IAAQDQQPDL CALLLAHGAD 

       430        440        450        460        470        480 
ANRVDEDGWA PLHFAAQNGD DGTARLLLDH GACVDAQERE GWTPLHLAAQ NNFENVARLL 

       490        500        510        520        530        540 
VSRQADPNLH EAEGKTPLHV AAYFGHVSLV KLLTSQGAEL DAQQRNLRTP LHLAVERGKV 

       550        560        570        580        590        600 
RAIQHLLKSG AVPDALDQSG YGPLHTAAAR GKYLICKMLL RYGASLELPT HQGWTPLHLA 

       610        620        630        640        650        660 
AYKGHLEIIH LLAESHANMG ALGAVNWTPL HLAARHGEEA VVSALLQCGA DPNAAEQSGW 

       670        680        690        700        710        720 
TPLHLAVQRS TFLSVINLLE HHANVHARNK VGWTPAHLAA LKGNTAILKV LVEAGAQLDV 

       730        740        750        760 
QDGVSCTPLQ LALRSRKQGI MSFLEGKEPS VATLGGSKPG AEMEI 

Q8NFD2 in FASTA format

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