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UniProtKB/Swiss-Prot entry Q8NEM2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SHCBP_HUMAN
Primary accession number Q8NEM2
Secondary accession numbers Q96N60 Q9BVS0 Q9H6P6
Integrated into Swiss-Prot on December 20, 2005
Sequence was last modified on December 20, 2005 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 50)
Name and origin of the protein
Protein name SHC SH2 domain-binding protein 1
Synonyms None
Gene name
Name: SHCBP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-42; SER-44; SER-47; SER-273 AND SER-634, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK025662; BAB15208.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK055931; BAB71049.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000960; AAH00960.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030699; AAH30699.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_079021.3; -.
UniGene Hs.123253
3D structure databases
ModBase Q8NEM2.
Protein-protein interaction databases
IntAct Q8NEM2; 2.
PTM databases
PhosphoSite Q8NEM2; -.
Organism-specific databases
GeneCards GC16M045171; -.
HGNC HGNC:29547; SHCBP1.
GenAtlas SHCBP1.
MIM 611027; gene. [NCBI / EBI]
PharmGKB PA134931125; -.
GeneCards Q8NEM2.
Gene expression databases
ArrayExpress Q8NEM2; -.
CleanEx HS_SHCBP1; -.
GermOnline ENSG00000171241; Homo sapiens.
Family and domain databases
InterPro IPR006626; PbH1.
Graphical view of domain structure.
SMART SM00710; PbH1; 5.
SMART graphical view of domain structure.
Proteomics databases
PRIDE Q8NEM2; -.
Genome annotation databases
Ensembl ENSG00000171241; Homo sapiens. [Contig view]
GeneID 79801; -.
KEGG hsa:79801; -.
Phylogenomic databases
HOGENOM Q8NEM2; -.
HOVERGEN Q8NEM2; -.
Other
NextBio 69364; -.
SOURCE SHCBP1; Homo sapiens.
ProtoNet Q8NEM2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Phosphoprotein; Polymorphism; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   672  672     SHC SH2 domain-binding protein 1. PRO_0000076315
REPEAT   428   451  24     PbH1 1. 
REPEAT   452   473  22     PbH1 2. 
REPEAT   474   496  23     PbH1 3. 
REPEAT   497   518  22     PbH1 4. 
REPEAT   526   548  23     PbH1 5. 
COMPBIAS   211   216  6     Poly-Glu. 
MOD_RES   31    31        Phosphoserine. 
MOD_RES   42    42        Phosphoserine. 
MOD_RES   44    44        Phosphoserine. 
MOD_RES   47    47        Phosphoserine. 
MOD_RES   273   273        Phosphoserine. 
MOD_RES   634   634        Phosphoserine. 
VARIANT   21    21  1     T -> M (in dbSNP:rs6598679 [NCBI]). VAR_051354 
VARIANT   60    60  1     M -> R (in dbSNP:rs11545690 [NCBI]). VAR_051355 
CONFLICT   118   118        V -> A (in Ref. 1; BAB71049). 
CONFLICT   329   329        Q -> R (in Ref. 1; BAB71049). 
CONFLICT   437   437        K -> R (in Ref. 1; BAB15208). 
CONFLICT   450   450        V -> A (in Ref. 1; BAB15208). 
CONFLICT   558   558        N -> S (in Ref. 2; AAH30699). 
Sequence information
Length: 672 AA [This is the length of the unprocessed precursor] Molecular weight: 75660 Da [This is the MW of the unprocessed precursor] CRC64: 564876E183EFCC2E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MADGSLTGGG LEAAAMAPER TGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM 

        70         80         90        100        110        120 
PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH 

       130        140        150        160        170        180 
TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV 

       190        200        210        220        230        240 
VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP 

       250        260        270        280        290        300 
SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK 

       310        320        330        340        350        360 
LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE 

       370        380        390        400        410        420 
REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG 

       430        440        450        460        470        480 
DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK 

       490        500        510        520        530        540 
NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE 

       550        560        570        580        590        600 
GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA 

       610        620        630        640        650        660 
RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK 

       670 
WNGKGSFGTF LF 

Q8NEM2 in FASTA format

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