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UniProtKB/Swiss-Prot entry Q8NE62

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CHDH_HUMAN
Primary accession number Q8NE62
Secondary accession number Q9NY17
Integrated into Swiss-Prot on February 16, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 55)
Name and origin of the protein
Protein name Choline dehydrogenase, mitochondrial [Precursor]
Synonyms CHD
CDH
EC 1.1.99.1
Gene name
Name: CHDH
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 113-594.
TISSUE=Kidney;
Bugert P., Hanke S., Chudek J., Kovacs G.;
"Analysis of a putative tumor suppressor gene region of 100 kb at chromosome 3p21.1 in conventional renal cell carcinoma.";
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC034502; AAH34502.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ272267; CAB75961.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060867.1; -.
UniGene Hs.126688
3D structure databases
HSSP Q945K2; 1JU2. [HSSP ENTRY / PDB]
ModBase Q8NE62.
PTM databases
PhosphoSite Q8NE62; -.
Organism-specific databases
GeneCards GC03M053826; -.
HGNC HGNC:24288; CHDH.
GenAtlas CHDH.
PharmGKB PA134873121; -.
GeneCards Q8NE62.
Gene expression databases
ArrayExpress Q8NE62; -.
CleanEx HS_CHDH; -.
GermOnline ENSG00000016391; Homo sapiens.
Ontologies
GO
GO:0008812; Molecular function: choline dehydrogenase activity (inferred from electronic annotation from EC).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0006066; Biological process: cellular alcohol metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.
Pfam PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000137; Alcohol_oxidase; 1.
PROSITE PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.
Proteomics databases
PRIDE Q8NE62; -.
Genome annotation databases
Ensembl ENSG00000016391; Homo sapiens. [Contig view]
GeneID 55349; -.
KEGG hsa:55349; -.
Phylogenomic databases
HOGENOM Q8NE62; -.
HOVERGEN Q8NE62; -.
Other
DrugBank DB00122; Choline.
NextBio 59691; -.
ProtoNet Q8NE62.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Polymorphism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   594        Choline dehydrogenase, mitochondrial. PRO_0000012329
NP_BIND   42    71  30     FAD (By similarity). 
ACT_SITE   511   511        By similarity. 
MOD_RES   496   496        N6-acetyllysine (By similarity). 
VARIANT   40    40  1     E -> A (in dbSNP:rs9001 [NCBI]). VAR_020421 
VARIANT   441   441  1     N -> S (in dbSNP:rs34974961 [NCBI]). VAR_049357 
CONFLICT   113   113        R -> A (in Ref. 2; CAB75961). 
Sequence information
Length: 594 AA [This is the length of the unprocessed precursor] Molecular weight: 65401 Da [This is the MW of the unprocessed precursor] CRC64: E9764CD0F4117A21 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MWCLLRGLGR PGALARGALG QQQSLGARAL ASAGSESRDE YSYVVVGAGS AGCVLAGRLT 

        70         80         90        100        110        120 
EDPAERVLLL EAGPKDVRAG SKRLSWKIHM PAALVANLCD DRYNWCYHTE VQRGLDGRVL 

       130        140        150        160        170        180 
YWPRGRVWGG SSSLNAMVYV RGHAEDYERW QRQGARGWDY AHCLPYFRKA QGHELGASRY 

       190        200        210        220        230        240 
RGADGPLRVS RGKTNHPLHC AFLEATQQAG YPLTEDMNGF QQEGFGWMDM TIHEGKRWSA 

       250        260        270        280        290        300 
ACAYLHPALS RTNLKAEAET LVSRVLFEGT RAVGVEYVKN GQSHRAYASK EVILSGGAIN 

       310        320        330        340        350        360 
SPQLLMLSGI GNADDLKKLG IPVVCHLPGV GQNLQDHLEI YIQQACTRPI TLHSAQKPLR 

       370        380        390        400        410        420 
KVCIGLEWLW KFTGEGATAH LETGGFIRSQ PGVPHPDIQF HFLPSQVIDH GRVPTQQEAY 

       430        440        450        460        470        480 
QVHVGPMRGT SVGWLKLRSA NPQDHPVIQP NYLSTETDIE DFRLCVKLTR EIFAQEALAP 

       490        500        510        520        530        540 
FRGKELQPGS HIQSDKEIDA FVRAKADSAY HPSCTCKMGQ PSDPTAVVDP QTRVLGVENL 

       550        560        570        580        590 
RVVDASIMPS MVSGNLNAPT IMIAEKAADI IKGQPALWDK DVPVYKPRTL ATQR
Q8NE62 in FASTA format

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