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UniProtKB/Swiss-Prot entry Q8NBX0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SCPDH_HUMAN
Primary accession number Q8NBX0
Secondary accession numbers Q8TAR0 Q9Y363
Integrated into Swiss-Prot on August 30, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 43)
Name and origin of the protein
Protein name Probable saccharopine dehydrogenase
Synonym EC 1.5.1.9
Gene name
Name: SCCPDH
ORFNames: CGI-49
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.10.5.703; PubMed=10810093 [NCBI, ExPASy, EBI, Israel, Japan]
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.";
Genome Res. 10:703-713(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF151807; AAD34044.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK075178; BAC11453.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591848; CAH73844.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026185; AAH26185.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_057086.2; -.
UniGene Hs.498397
3D structure databases
ModBase Q8NBX0.
PTM databases
PhosphoSite Q8NBX0; -.
Organism-specific databases
GeneCards GC01P244953; -.
HGNC HGNC:24275; SCCPDH.
GenAtlas SCCPDH.
PharmGKB PA142670949; -.
GeneCards Q8NBX0.
Gene expression databases
ArrayExpress Q8NBX0; -.
CleanEx HS_SCCPDH; -.
GermOnline ENSG00000143653; Homo sapiens.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0047131; Molecular function: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR005097; Saccharopine_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF03435; Saccharop_dh; 1.
Pfam graphical view of domain structure.
Proteomic databases
PeptideAtlas Q8NBX0; -.
Proteomics databases
PRIDE Q8NBX0; -.
Genome annotation databases
Ensembl ENSG00000143653; Homo sapiens. [Contig view]
GeneID 51097; -.
KEGG hsa:51097; -.
Phylogenomic databases
HOGENOM Q8NBX0; -.
HOVERGEN Q8NBX0; -.
Other
NextBio 53797; -.
ProtoNet Q8NBX0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   429  429     Probable saccharopine dehydrogenase. PRO_0000212840
VARIANT   418   418  1     G -> R (in dbSNP:rs7779 [NCBI]). VAR_034486 
CONFLICT   37    43        SSRLPWA -> TQPALG (in Ref. 1; AAD34044). 
CONFLICT   187   187        P -> H (in Ref. 4; AAH26185). 
CONFLICT   347   347        Q -> R (in Ref. 4; AAH26185). 
Sequence information
Length: 429 AA [This is the length of the unprocessed precursor] Molecular weight: 47151 Da [This is the MW of the unprocessed precursor] CRC64: A93EBEDDF128A548 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE KLQRVLEKAA 

        70         80         90        100        110        120 
LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVLNCVG PYRFYGEPVI KACIENGASC 

       130        140        150        160        170        180 
IDISGEPQFL ELMQLKYHEK AADKGVYIIG SSGFDSIPAD LGVIYTRNKM NGTLTAVESF 

       190        200        210        220        230        240 
LTIHSGPEGL SIHDGTWKSA IYGFGDQSNL RKLRNVSNLK PVPLIGPKLK RRWPISYCRE 

       250        260        270        280        290        300 
LKGYSIPFMG SDVSVVRRTQ RYLYENLEES PVQYAAYVTV GGITSVIKLM FAGLFFLFFV 

       310        320        330        340        350        360 
RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGTG TDKNKPNIKI 

       370        380        390        400        410        420 
CTQVKGPEAG YVATPIAMVQ AAMTLLSDAS HLPKAGGVFT PGAAFSKTKL IDRLNKHGIE 


FSVISSSEV 

Q8NBX0 in FASTA format

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