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UniProtKB/Swiss-Prot entry Q8N720


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ZN655_HUMAN
Primary accession number Q8N720
Secondary accession numbers Q8IV00 Q8TA89 Q96EZ3 Q9BQ85
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on October 17, 2006 (Sequence version 3)
Annotations were last modified on    December 16, 2008 (Entry version 51)
Name and origin of the protein
Protein name Zinc finger protein 655
Synonym Vav-interacting Krueppel-like protein
Gene name
Name: ZNF655
Synonyms: VIK
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH VAV1 AND CDK4.
DOI=10.1038/sj.onc.1208043; PubMed=15558030 [NCBI, ExPASy, EBI, Israel, Japan]
Houlard M., Romero-Portillo F., Germani A., Depaux A., Regnier-Ricard F., Gisselbrecht S., Varin-Blank N.;
"Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.";
Oncogene 24:28-38(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1083423; PubMed=12690205 [NCBI, ExPASy, EBI, Israel, Japan]
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT ASP-52.
TISSUE=Brain, Cervix, Pancreas, Placenta, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY099353; AAM33786.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC005020; AAS02017.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH236956; EAL23871.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471091; EAW76650.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000823; AAH00823.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC004288; AAH04288.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007378; AAH07378.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011816; AAH11816.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024770; AAH24770.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC037407; AAH37407.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001009960.1; -.
NP_612503.1; -.
UniGene Hs.696221
3D structure databases
HSSP P08045; 1ZNF. [HSSP ENTRY / PDB]
ModBase Q8N720.
Protein-protein interaction databases
IntAct Q8N720; 2.
Organism-specific databases
GeneCards GC07P098993; -.
HGNC HGNC:30899; ZNF655.
GenAtlas ZNF655.
PharmGKB PA134883537; -.
GeneCards Q8N720.
Gene expression databases
ArrayExpress Q8N720; -.
CleanEx HS_ZNF655; -.
GermOnline ENSG00000197343; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
Pfam PF00096; zf-C2H2; 6.
Pfam graphical view of domain structure.
ProDom PD000003; Znf_C2H2; 5.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00355; ZnF_C2H2; 7.
SMART graphical view of domain structure.
PROSITE PS00028; ZINC_FINGER_C2H2_1; 6.
PS50157; ZINC_FINGER_C2H2_2; 6.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas Q8N720; -.
Proteomics databases
PRIDE Q8N720; -.
Genome annotation databases
Ensembl ENSG00000197343; Homo sapiens. [Contig view]
GeneID 79027; -.
Phylogenomic databases
HOGENOM Q8N720; -.
HOVERGEN Q8N720; -.
Other
LinkHub Q8N720; -.
NextBio 67721; -.
ProtoNet Q8N720.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   491  491     Zinc finger protein 655. PRO_0000047700
ZN_FING   212   234  23     C2H2-type 1. 
ZN_FING   240   262  23     C2H2-type 2. 
ZN_FING   303   325  23     C2H2-type 3. 
ZN_FING   330   353  24     C2H2-type 4. 
ZN_FING   380   402  23     C2H2-type 5. 
ZN_FING   408   430  23     C2H2-type 6. 
MOD_RES   12    12        Phosphoserine. 
VAR_SEQ   46   181        DGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPE TREVYKSEDRLERLQEILRKFLYLEREFRQITISKETFTS EKNNECHEPEKSFSLDSTIDADQRVLRIQNTDDNDKYDMS FNQNSASGKHEHLNLT -> APPVPQVPALPREGSPGDQAAALLTARYQEFVTFEDVAVH LTREEWGYLDPVQRDLYREVMLENYGNVVSLGILLRLPTT RIHSVNSCPALSHTQASAFSGETLAVLTAGISKRWPKYRL PIDIARPCSETPFPRL (in isoform 2). VSP_036030
VAR_SEQ   182   491        Missing (in isoform 2). VSP_036031
VARIANT   52    52  1     E -> D. VAR_028165 
Sequence information
Length: 491 AA [This is the length of the unprocessed precursor] Molecular weight: 57407 Da [This is the MW of the unprocessed precursor] CRC64: 04FD791D769C3A80 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEEIPAQEAA GSPRVQFQSL ETQSECLSPE PQFVQDTDME QGLTGDGETR EENKLLIPKQ 

        70         80         90        100        110        120 
KISEEVHSYK VRVGRLKHDI TQVPETREVY KSEDRLERLQ EILRKFLYLE REFRQITISK 

       130        140        150        160        170        180 
ETFTSEKNNE CHEPEKSFSL DSTIDADQRV LRIQNTDDND KYDMSFNQNS ASGKHEHLNL 

       190        200        210        220        230        240 
TEDFQSSECK ESLMDLSHLN KWESIPNTEK SYKCDVCGKI FHQSSALTRH QRIHTREKPY 

       250        260        270        280        290        300 
KCKECEKSFS QSSSLSRHKR IHTREKPYKC EASDKSCEAS DKSCSPSSGI IQHKKIHTRA 

       310        320        330        340        350        360 
KSYKCSSCER VFSRSVHLTQ HQKIHKEMPC KCTVCGSDFC HTSYLLEHQR VHHEEKAYEY 

       370        380        390        400        410        420 
DEYGLAYIKQ QGIHFREKPY TCSECGKDFR LNSHLIQHQR IHTGEKAHEC NECGKAFSQT 

       430        440        450        460        470        480 
SCLIQHHKMH RKEKSYECNE YEGSFSHSSD LILQQEVLTR QKAFDCDVWE KNSSQRAHLV 

       490 
QHQSIHTKEN S 

Q8N720 in FASTA format

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