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UniProtKB/Swiss-Prot entry Q8N2A8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PLD6_HUMAN
Primary accession number Q8N2A8
Secondary accession number Q8N5Y1
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 37)
Name and origin of the protein
Protein name Phospholipase D6
Synonyms PLD 6
EC 3.1.4.4
Choline phosphatase 6
Phosphatidylcholine-hydrolyzing phospholipase D6
Gene name
Name: PLD6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Amygdala;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-42 AND HIS-108.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK090899; BAC03541.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC031263; AAH31263.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_849158.1; -.
UniGene Hs.31652
3D structure databases
HSSP Q46707; 1BYR. [HSSP ENTRY / PDB]
ModBase Q8N2A8.
Organism-specific databases
GeneCards GC17M017046; -.
HGNC HGNC:30447; PLD6.
GenAtlas PLD6.
GeneCards Q8N2A8.
Gene expression databases
ArrayExpress Q8N2A8; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004630; Molecular function: phospholipase D activity (inferred from electronic annotation from EC).
GO:0016042; Biological process: lipid catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001736; PLD.
Graphical view of domain structure.
Pfam PF00614; PLDc; 1.
Pfam graphical view of domain structure.
SMART SM00155; PLDc; 1.
SMART graphical view of domain structure.
PROSITE PS50035; PLD; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8N2A8; -.
Genome annotation databases
Ensembl ENSG00000179598; Homo sapiens. [Contig view]
GeneID 201164; -.
KEGG hsa:201164; -.
Phylogenomic databases
HOGENOM Q8N2A8; -.
HOVERGEN Q8N2A8; -.
Other
NextBio 90067; -.
ProtoNet Q8N2A8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Hydrolase; Lipid degradation; Membrane; Polymorphism; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   252  252     Phospholipase D6. PRO_0000325910
TRANSMEM   5    27  23     Potential. 
DOMAIN   151   178  28     PLD phosphodiesterase. 
ACT_SITE   156   156        Potential. 
ACT_SITE   158   158        Potential. 
ACT_SITE   163   163        Potential. 
CARBOHYD   132   132        N-linked (GlcNAc...) (Potential). 
VARIANT   42    42  1     L -> P (in dbSNP:rs17856924 [NCBI]). VAR_039951 
VARIANT   108   108  1     R -> H (in dbSNP:rs11551966 [NCBI]). VAR_039952 
Sequence information
Length: 252 AA [This is the length of the unprocessed precursor] Molecular weight: 28273 Da [This is the MW of the unprocessed precursor] CRC64: CE3A205C1D42B497 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGRLSWQVAA AAAVGLALTL EALPWVLRWL RSRRRRPRRE ALFFPSQVTC TEALLRAPGA 

        70         80         90        100        110        120 
ELAELPEGCP CGLPHGESAL SRLLRALLAA RASLDLCLFA FSSPQLGRAV QLLHQRGVRV 

       130        140        150        160        170        180 
RVVTDCDYMA LNGSQIGLLR KAGIQVRHDQ DPGYMHHKFA IVDKRVLITG SLNWTTQAIQ 

       190        200        210        220        230        240 
NNRENVLITE DDEYVRLFLE EFERIWEQFN PTKYTFFPPK KSHGSCAPPV SRAGGRLLSW 

       250 
HRTCGTSSES QT 

Q8N2A8 in FASTA format

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