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UniProtKB/Swiss-Prot entry Q8N1F7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUP93_HUMAN
Primary accession number Q8N1F7
Secondary accession number Q14705
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on October 17, 2006 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 50)
Name and origin of the protein
Protein name Nuclear pore complex protein Nup93
Synonyms Nucleoporin Nup93
93 kDa nucleoporin
Gene name
Name: NUP93
Synonyms: KIAA0095
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone marrow;
DOI=10.1093/dnares/2.1.37; PubMed=7788527 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.";
DNA Res. 2:37-43(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-509.
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
CHARACTERIZATION.
PubMed=9348540 [NCBI, ExPASy, EBI, Israel, Japan]
Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., Hurt E.;
"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly.";
Mol. Biol. Cell 8:2017-2038(1997).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-767, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-72, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D42085; BAA07680.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034346; AAH34346.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_055484.3; -.
UniGene Hs.276878
3D structure databases
ModBase Q8N1F7.
Protein-protein interaction databases
IntAct Q8N1F7; 17.
PTM databases
PhosphoSite Q8N1F7; -.
Enzyme and pathway databases
Reactome REACT_6185; HIV Infection.
Organism-specific databases
GeneCards GC16P055322; -.
H-InvDB HIX0013063; -.
HGNC HGNC:28958; NUP93.
GenAtlas NUP93.
HPA HPA017937; -.
PharmGKB PA134912759; -.
GeneCards Q8N1F7.
HUGE KIAA0095.
Gene expression databases
ArrayExpress Q8N1F7; -.
CleanEx HS_NUP93; -.
GermOnline ENSG00000102900; Homo sapiens.
Ontologies
GO
GO:0005643; Cellular component: nuclear pore (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0065002; Biological process: intracellular protein transmembrane transport (inferred from electronic annotation from UniProtKB-KW).
GO:0051028; Biological process: mRNA transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007231; Nucleoporin_intact_comp.
Graphical view of domain structure.
PANTHER PTHR11225; NIC; 1.
Pfam PF04097; NIC; 1.
Pfam graphical view of domain structure.
Proteomics databases
PRIDE Q8N1F7; -.
Genome annotation databases
Ensembl ENSG00000102900; Homo sapiens. [Contig view]
GeneID 9688; -.
KEGG hsa:9688; -.
Phylogenomic databases
HOGENOM Q8N1F7; -.
HOVERGEN Q8N1F7; -.
Other
NextBio 36387; -.
ProtoNet Q8N1F7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Translocation; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   819  819     Nuclear pore complex protein Nup93. PRO_0000124782
MOD_RES   52    52        Phosphoserine. 
MOD_RES   72    72        Phosphoserine. 
MOD_RES   430   430        Phosphoserine. 
MOD_RES   767   767        Phosphoserine. 
VARIANT   509   509  1     S -> R (in dbSNP:rs17853288 [NCBI]). VAR_028160 
Sequence information
Length: 819 AA [This is the length of the unprocessed precursor] Molecular weight: 93488 Da [This is the MW of the unprocessed precursor] CRC64: 7A611FABE964FE98 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 

        70         80         90        100        110        120 
SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 

       130        140        150        160        170        180 
TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN 

       190        200        210        220        230        240 
IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD 

       250        260        270        280        290        300 
ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 

       310        320        330        340        350        360 
LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD 

       370        380        390        400        410        420 
RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ 

       430        440        450        460        470        480 
VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAVAFLF 

       490        500        510        520        530        540 
RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCLRRLNFVR LLMLYTRKFE 

       550        560        570        580        590        600 
STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 

       610        620        630        640        650        660 
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 

       670        680        690        700        710        720 
ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV 

       730        740        750        760        770        780 
PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED 

       790        800        810 
RDSQLRSQAR TLITFAGMIP YRTSGDTNAR LVQMEVLMN 

Q8N1F7 in FASTA format

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