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UniProtKB/Swiss-Prot entry Q8MHW6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name URIC_MACFA
Primary accession number Q8MHW6
Secondary accession numbers None
Integrated into Swiss-Prot on April 12, 2005
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 35)
Name and origin of the protein
Protein name Uricase
Synonyms EC 1.7.3.3
Urate oxidase
Gene name
Name: UOX
From
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Liver;
PubMed=11961098 [NCBI, ExPASy, EBI, Israel, Japan]
Oda M., Satta Y., Takenaka O., Takahata N.;
"Loss of urate oxidase activity in hominoids and its evolutionary implications.";
Mol. Biol. Evol. 19:640-653(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB074382; BAB91556.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP Q00511; 1R51. [HSSP ENTRY / PDB]
ModBase Q8MHW6.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0004846; Molecular function: urate oxidase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006144; Biological process: purine base metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002042; Uricase.
Graphical view of domain structure.
Gene3D G3DSA:3.10.270.10; Uricase; 1.
PANTHER PTHR10395:SF1; Uricase; 1.
Pfam PF01014; Uricase; 2.
Pfam graphical view of domain structure.
PRINTS PR00093; URICASE.
ProDom PD003367; Uricase; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03383; urate_oxi; 1.
PROSITE PS00366; URICASE; 1.
Phylogenomic databases
HOVERGEN Q8MHW6; -.
Other
ProtoNet Q8MHW6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Oxidoreductase; Peroxisome; Phosphoprotein; Purine metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   304  303     Uricase. PRO_0000165984
MOTIF   302   304  3     Microbody targeting signal (Potential). 
ACT_SITE   187   187        Charge relay system (By similarity). 
ACT_SITE   236   236        Charge relay system (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   36    36        N6-acetyllysine (By similarity). 
MOD_RES   39    39        Phosphoserine (By similarity). 
MOD_RES   55    55        N6-acetyllysine (By similarity). 
MOD_RES   118   118        N6-acetyllysine (By similarity). 
MOD_RES   122   122        N6-acetyllysine (By similarity). 
MOD_RES   164   164        N6-acetyllysine (By similarity). 
MOD_RES   185   185        N6-acetyllysine (By similarity). 
MOD_RES   221   221        N6-acetyllysine (By similarity). 
MOD_RES   228   228        N6-acetyllysine (By similarity). 
MOD_RES   232   232        Phosphoserine (By similarity). 
MOD_RES   278   278        N6-acetyllysine (By similarity). 
MOD_RES   291   291        N6-acetyllysine (By similarity). 
MOD_RES   302   302        Phosphoserine (By similarity). 
Sequence information
Length: 304 AA [This is the length of the unprocessed precursor] Molecular weight: 34978 Da [This is the MW of the unprocessed precursor] CRC64: D320AFF27870FAE5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MADYHNNYKK NDELEFVRTG YGKDMVKVLH IQRDGKYHSI KEVATSVQLT LSSKKDYLHG 

        70         80         90        100        110        120 
DNSDIIPTDT IKNTVHVLAK FKGIKSIEAF GVNICEYFLS SFNHVIRAQV YVEEIPWKRL 

       130        140        150        160        170        180 
EKNGVKHVHA FIHTPTGTHF CEVEQLRSGP PVIHSGIKDL KVLKTTQSGF EGFIKDQFTT 

       190        200        210        220        230        240 
LPEVKDRCFA TQVYCKWRYH QCRDVDFEAT WGTIRDLVLE KFAGPYDKGE YSPSVQKTLY 

       250        260        270        280        290        300 
DIQVLSLSRV PEIEDMEISL PNIHYFNIDM SKMGLINKEE VLLPLDNPYG KITGTVKRKL 


SSRL
Q8MHW6 in FASTA format

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