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[1]
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NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
DOI=10.1093/nar/gkf660; PubMed=12466527 [NCBI, ExPASy, EBI, Israel, Japan]
Pandey R.,
Mueller A.,
Napoli C.A.,
Selinger D.A.,
Pikaard C.S.,
Richards E.J.,
Bender J.,
Mount D.W.,
Jorgensen R.A.;
"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes.";
Nucleic Acids Res. 30:5036-5055(2002).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1093/dnares/4.4.291; PubMed=9405937 [NCBI, ExPASy, EBI, Israel, Japan]
Kotani H.,
Nakamura Y.,
Sato S.,
Kaneko T.,
Asamizu E.,
Miyajima N.,
Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence features of the regions of 1,044,062 bp covered by thirteen physically assigned P1 clones.";
DNA Res. 4:291-300(1997).
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[3]
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FUNCTION.
DOI=10.1073/pnas.0503143102; PubMed=16176989 [NCBI, ExPASy, EBI, Israel, Japan]
Xu C.-R.,
Liu C.,
Wang Y.-L.,
Li L.-C.,
Chen W.-Q.,
Xu Z.-H.,
Bai S.-N.;
"Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis.";
Proc. Natl. Acad. Sci. U.S.A. 102:14469-14474(2005).
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- FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
- CATALYTIC ACTIVITY: Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.
- SUBCELLULAR LOCATION: Nucleus (By similarity).
- MISCELLANEOUS: HDA5, a tandem duplication of HDA18, is not required for the cellular patterning in the root epidermis.
- SIMILARITY: Belongs to the histone deacetylase family. Type 2 subfamily.
- SEQUENCE CAUTION:
- Sequence=BAB10370.1; Type=Erroneous gene model prediction;
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 682 AA [This is the length of the unprocessed precursor] |
Molecular weight: 76634 Da [This is the MW of the unprocessed precursor] |
CRC64: 67D91533AB998840 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLLKFEASSE LRLVDPSVSL TVLRKIRLSH LPDMTMTSES SGKKCGEGDG KVAGKSQRKV
70 80 90 100 110 120
GLVYDETMCK HDTPNGKVDV ECPDRIRVIW EKLQLAGVTQ RCVVLGGSKA EDKHLKLVHT
130 140 150 160 170 180
KKHVNLVKSI STKKKDSRRN KIASQLDSIY LNGGSSEAAY LAAGSVVKVA EKVAEGELDC
190 200 210 220 230 240
GFAIVRPPGH HAESDEAMGF CLFNNVAVAA SFLLNERPDL DVKKILIVDW DIHHGNGTQK
250 260 270 280 290 300
MFWKDSRVLI FSVHRHDHGS FYPFGDDGDF NMVGEGPGEG FNINVPWEQG GCGDADYLAV
310 320 330 340 350 360
WNHILIPVTK EFKPDIILLS AGFDAAIGDP LGGCCVTPYG YSVMLKKLME FAHGKIVLAL
370 380 390 400 410 420
EGGYNLESLG KSSLACVQVL LEDKQIHGSS ETYPLESTRR VIQAVRERLC TYWPSLDASM
430 440 450 460 470 480
ASNENLKNPS AERNSADALL REVEELKSLM AARDGELEAR RKELKAKNKE LEANEKELEA
490 500 510 520 530 540
GLMLIRARED VICGLHAKIE SLQQERDEAV AKAERIDKEL QEDRARSQEF KEDTEFCLST
550 560 570 580 590 600
LRREKELAIM AKNKDLEAKE KELEARLMLV HAREDKIHAK IERLQQERDE AVAKAERIDK
610 620 630 640 650 660
ELQEDRSRSR VGNGSFAFSQ EFYEDMDLDE LEPLSPEFNE DMDSEELEPF QVIKKNMERS
670 680
HKKFIKDMEC IKFIASERAR VL
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Q8LRK8 in FASTA format |
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