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UniProtKB/Swiss-Prot entry Q8KG43

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DXR_CHLTE
Primary accession number Q8KG43
Secondary accession numbers None
Integrated into Swiss-Prot on June 20, 2003
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 36)
Name and origin of the protein
Protein name 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms DXP reductoisomerase
EC 1.1.1.267
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene name
Name: dxr
OrderedLocusNames: CT0125
From
Chlorobium tepidum [TaxID: 1097] [HAMAP proteome]
Taxonomy Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / TLS;
DOI=10.1073/pnas.132181499; PubMed=12093901 [NCBI, ExPASy, EBI, Israel, Japan]
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006470; AAM71373.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_661031.1; -.
3D structure databases
HSSP P45568; 1K5H. [HSSP ENTRY / PDB]
ModBase Q8KG43.
Enzyme and pathway databases
BioCyc CTEP194439:CT_0125-MON; -.
Ontologies
GO
GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0016114; Biological process: terpenoid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00183; -; 1.
PBIL [Tree]
InterPro IPR003821; DXP_reductoisomerase.
IPR013644; DXP_reductoisomerase_C.
IPR013512; DXP_reductoisomerase_N.
Graphical view of domain structure.
Pfam PF08436; DXP_redisom_C; 1.
PF02670; DXP_reductoisom; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF006205; Dxp_reductismrs; 1.
TIGRFAMs TIGR00243; Dxr; 1.
Genome annotation databases
GeneID 1006807; -.
GenomeReviews AE006470_GR; CT0125.
KEGG cte:CT0125; -.
NMPDR fig|194439.1.peg.125; -.
TIGR CT0125; -.
Phylogenomic databases
HOGENOM Q8KG43; -.
Other
ProtoNet Q8KG43.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   382  382     1-deoxy-D-xylulose 5-phosphate reductoisomerase. PRO_0000163634
NP_BIND   7    36  30     NADP (By similarity). 
METAL   148   148        Divalent metal cation (By similarity). 
METAL   150   150        Divalent metal cation (By similarity). 
METAL   219   219        Divalent metal cation (By similarity). 
BINDING   123   123        Substrate (By similarity). 
BINDING   150   150        Substrate (By similarity). 
BINDING   174   174        Substrate (By similarity). 
BINDING   197   197        Substrate (By similarity). 
BINDING   219   219        Substrate (By similarity). 
Sequence information
Length: 382 AA [This is the length of the unprocessed precursor] Molecular weight: 41344 Da [This is the MW of the unprocessed precursor] CRC64: 4B42A8B6F36368CA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKSLSILGST GSIGLSTLDV VRRHPERFSI AALAEGHDVE MLLKQIDEFR PSLVSVRDEA 

        70         80         90        100        110        120 
SRERLKGMLG DHKPEILCGL EGAAEVAAVD GADMVVSAIV GAAGLVPTVR AIEAGKDIAL 

       130        140        150        160        170        180 
ANKETLVVAG QLVSDLVKKH DVKLLPVDSE HSAIFQSLVG HRTEDIERII LTASGGPFRK 

       190        200        210        220        230        240 
TPAEELKNVG PEQALKHPQW SMGAKITIDS ATLMNKGLEV IEAHWLFDMP AEKIGVVVHP 

       250        260        270        280        290        300 
QSIIHSMVEY IDGCVIAQLG VPDMRAPIAY ALAWPERCET GIGKLDLTKV ATLTFEEPDM 

       310        320        330        340        350        360 
ERFPALRLAF DALKAGQTYP AVLNAANEIA VAAFLDKKIG FTDIAGTVDK TMQAHEAWTP 

       370        380 
ITLEEYLQAD KWARETARQL IG
Q8KG43 in FASTA format

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