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UniProtKB/Swiss-Prot entry Q8KEA8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCH1_CHLTE
Primary accession number Q8KEA8
Secondary accession numbers None
Integrated into Swiss-Prot on November 15, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name GTP cyclohydrolase 1
Synonyms EC 3.5.4.16
GTP cyclohydrolase I
GTP-CH-I
Gene name
Name: folE
OrderedLocusNames: CT0781
From
Chlorobium tepidum [TaxID: 1097] [HAMAP proteome]
Taxonomy Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / TLS;
DOI=10.1073/pnas.132181499; PubMed=12093901 [NCBI, ExPASy, EBI, Israel, Japan]
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006470; AAM72018.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_661676.1; -.
3D structure databases
HSSP P22288; 1IS8. [HSSP ENTRY / PDB]
ModBase Q8KEA8.
Enzyme and pathway databases
BioCyc CTEP194439:CT_0781-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0003934; Molecular function: GTP cyclohydrolase I activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0019438; Biological process: aromatic compound biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
GO:0046654; Biological process: tetrahydrofolate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00223; -; 1.
PBIL [Tree]
InterPro IPR001474; GTP_CycOHase_I.
Graphical view of domain structure.
PANTHER PTHR11109; GTP_cyclohydro_I; 1.
Pfam PF01227; GTP_cyclohydroI; 1.
Pfam graphical view of domain structure.
ProDom PD003330; GTP_cyclohydroI; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00063; folE; 1.
PROSITE PS00859; GTP_CYCLOHYDROL_1_1; 1.
PS00860; GTP_CYCLOHYDROL_1_2; 1.
Genome annotation databases
GeneID 1006416; -.
GenomeReviews AE006470_GR; CT0781.
KEGG cte:CT0781; -.
NMPDR fig|194439.1.peg.770; -.
TIGR CT0781; -.
Phylogenomic databases
HOGENOM Q8KEA8; -.
Other
ProtoNet Q8KEA8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; One-carbon metabolism; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   224  224     GTP cyclohydrolase 1. PRO_0000119396
METAL   114   114        Zinc (By similarity). 
METAL   117   117        Zinc (By similarity). 
METAL   185   185        Zinc (By similarity). 
Sequence information
Length: 224 AA [This is the length of the unprocessed precursor] Molecular weight: 25368 Da [This is the MW of the unprocessed precursor] CRC64: F2E4A9B7157D7807 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKQEKTVSPT VENNRSAESR LSQCDLDECF DESHDRDEEV LGSMTDAVYS LLKGVGEDPE 

        70         80         90        100        110        120 
REGLLLTPER VAKSLRFLTK GYRQDPEQLL KKAVFTESYD EMVLVKDIDI YSMCEHHMLP 

       130        140        150        160        170        180 
FFGKAHVAYI PDGKIVGLSK IPRVVEVFAR RLQVQERLTQ QIRDAIQNVL NPRGVAVVIE 

       190        200        210        220 
ATHMCMVMRG VEKQNAVTTT SAMSGDFMTS QSTRSEFLRL IGNH
Q8KEA8 in FASTA format

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