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UniProtKB/Swiss-Prot entry Q8KCJ0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM2_CHLTE
Primary accession number Q8KCJ0
Secondary accession numbers None
Integrated into Swiss-Prot on November 25, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 36)
Name and origin of the protein
Protein name Delta-aminolevulinic acid dehydratase
Synonyms ALADH
ALAD
EC 4.2.1.24
Porphobilinogen synthase
Gene name
Name: hemB
OrderedLocusNames: CT1431
From
Chlorobium tepidum [TaxID: 1097] [HAMAP proteome]
Taxonomy Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / TLS;
DOI=10.1073/pnas.132181499; PubMed=12093901 [NCBI, ExPASy, EBI, Israel, Japan]
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006470; AAM72659.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_662317.1; -.
3D structure databases
HSSP Q59643; 1B4K. [HSSP ENTRY / PDB]
SMR Q8KCJ0; 10-328.
ModBase Q8KCJ0.
Enzyme and pathway databases
BioCyc CTEP194439:CT_1431-MON; -.
Ontologies
GO
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004655; Molecular function: porphobilinogen synthase activity (inferred from electronic annotation from InterPro).
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001731; 4pyrrol_synth_porphobiln_synth.
IPR013785; Aldolase_TIM.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR11458; AlaD_dehydratase; 1.
Pfam PF00490; ALAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001415; Porphbilin_synth; 1.
PRINTS PR00144; DALDHYDRTASE.
ProDom PD002304; AlaD_dehydratase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00169; D_ALA_DEHYDRATASE; 1.
Genome annotation databases
GeneID 1005979; -.
GenomeReviews AE006470_GR; CT1431.
KEGG cte:CT1431; -.
NMPDR fig|194439.1.peg.1411; -.
TIGR CT1431; -.
Phylogenomic databases
HOGENOM Q8KCJ0; -.
Other
ProtoNet Q8KCJ0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Heme biosynthesis; Lyase; Magnesium; Porphyrin biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   328  328     Delta-aminolevulinic acid dehydratase. PRO_0000140497
ACT_SITE   253   253        By similarity. 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 36433 Da [This is the MW of the unprocessed precursor] CRC64: 55556CA0D0632148 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSQLDLLNIV HRPRRLRRTA ALRNLVQENT LTVNDLVFPL FVMPGTNAVE EVPSMPGSFR 

        70         80         90        100        110        120 
FTIDRAVEEC KELYDLGIQA IDLFGIPEKK TEDGSEAYND NGILQQAIRA IKKAVPELCI 

       130        140        150        160        170        180 
MTDVALDPFT PFGHDGLVRD GIILNDETVE VLQKMAVSHA EAGADFVSPS DMMDGRIGAI 

       190        200        210        220        230        240 
REALDESDHS DVGILSYAAK YASSFYGPFR DALHSAPQFG DKSTYQMNPA NTDEAMKEVE 

       250        260        270        280        290        300 
LDIIEGADIV MVKPGLAYLD IVWRTKERFD VPVAIYHVSG EYAMVKAAAA NGWIDEERVM 

       310        320 
MESLLCMKRA GADIIFTYYA KEAAKKLR
Q8KCJ0 in FASTA format

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