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UniProtKB/Swiss-Prot entry Q8KA05

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCH1_BUCAP
Primary accession number Q8KA05
Secondary accession numbers None
Integrated into Swiss-Prot on November 15, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name GTP cyclohydrolase 1
Synonyms EC 3.5.4.16
GTP cyclohydrolase I
GTP-CH-I
Gene name
Name: folE
OrderedLocusNames: BUsg_129
From
Buchnera aphidicola subsp. Schizaphis graminum [TaxID: 98794] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1071278; PubMed=12089438 [NCBI, ExPASy, EBI, Israel, Japan]
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
"50 million years of genomic stasis in endosymbiotic bacteria.";
Science 296:2376-2379(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE013218; AAM67697.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_660486.1; -.
3D structure databases
HSSP P27511; 1A8R. [HSSP ENTRY / PDB]
ModBase Q8KA05.
Enzyme and pathway databases
BioCyc BAPH198804:BUSG129-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0003934; Molecular function: GTP cyclohydrolase I activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0019438; Biological process: aromatic compound biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
GO:0046654; Biological process: tetrahydrofolate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00223; -; 1.
PBIL [Tree]
InterPro IPR001474; GTP_CycOHase_I.
Graphical view of domain structure.
PANTHER PTHR11109; GTP_cyclohydro_I; 1.
Pfam PF01227; GTP_cyclohydroI; 1.
Pfam graphical view of domain structure.
ProDom PD003330; GTP_cyclohydroI; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00063; folE; 1.
PROSITE PS00859; GTP_CYCLOHYDROL_1_1; 1.
PS00860; GTP_CYCLOHYDROL_1_2; 1.
Genome annotation databases
GeneID 1005946; -.
GenomeReviews AE013218_GR; BUsg_129.
KEGG bas:BUsg129; -.
Phylogenomic databases
HOGENOM Q8KA05; -.
Genome annotation databases
CMR Q8KA05; BUsg_129.
Other
ProtoNet Q8KA05.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; One-carbon metabolism; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   218  218     GTP cyclohydrolase 1. PRO_0000119392
METAL   111   111        Zinc (By similarity). 
METAL   114   114        Zinc (By similarity). 
METAL   182   182        Zinc (By similarity). 
Sequence information
Length: 218 AA [This is the length of the unprocessed precursor] Molecular weight: 25362 Da [This is the MW of the unprocessed precursor] CRC64: 9C801D5AE1C6B871 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIKITKEANI ARNVLLLKGL ENPILKEYND IKEKERELLI AEYLYKIMSL LNLDLKNESL 

        70         80         90        100        110        120 
KDTPIRISKM YVNEIFSGLD YKNFPKIMLM DNKIKFHEMI IVRDILLIST CEHHFITING 

       130        140        150        160        170        180 
QATIAYIPEN KIIGLSKINR IAQFFAKRPQ IQERLTKQIL LVLQVLLQTK NVAIIIHMDH 

       190        200        210 
FCVKARGVCD TSSSTVTSCL DGLFKSDKNI REEFFFKK
Q8KA05 in FASTA format

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