FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE013218; AAM67847.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_660636.1; -.

3D structure databases

ModBase

Q8K9N3.

Enzyme and pathway databases

BioCyc

BAPH198804:BUSG292-MON; -.

Ontologies

GO:0004591;	Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from electronic annotation from InterPro).
GO:0030976;	Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from InterPro).
GO:0006096;	Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

Genome annotation databases

GeneID

1005496; -.

GenomeReviews

AE013218_GR; BUsg_292.

KEGG

bas:BUsg292; -.

Phylogenomic databases

HOGENOM

Q8K9N3; -.

Genome annotation databases

CMR

Q8K9N3; BUsg_292.

Other

ProtoNet

Q8K9N3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 923`	`923`		`2-oxoglutarate dehydrogenase E1 component.`	`PRO_0000162188`

Sequence information

Length: 923 AA [This is the length of the unprocessed precursor]

Molecular weight: 107422 Da [This is the MW of the unprocessed precursor]

CRC64: 255A7653EED01A48 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKNTLEKWF NSSWLSGNNQ NYIEKIYESY LINPKSVDIT WQDKFSDLSK KRKNILKEEK 

        70         80         90        100        110        120 
FVYKNNSFKE IKIDKQEILE KKINYIINTF RKKGYKKSLI DPLKLNEQKK YKYLEPTFYH 

       130        140        150        160        170        180 
FSEDELKKTV KIDFKNSSQY EIKIRDLYEQ LNNKYCGSIG FEYMYIENSF EKKWITKHIE 

       190        200        210        220        230        240 
LFFKENLFIK KEKIRFLKEI LYGETFEKYL GKKFSGTKRF SLEGGETLIS ILHEIIRYSK 

       250        260        270        280        290        300 
KNDVSEIILG MAHRGRLNVL VNVLNKNPQV LFNEFSGINI PKEYSGDVKY HMGGITKIKN 

       310        320        330        340        350        360 
DKKKIYLKLA YNPSHLEIVN PVVLGIARAS INQLKISENK FLSINIHGDA SIIGQGVIQE 

       370        380        390        400        410        420 
TLNMSQTEAY KIGGTIHIVI NNQIGFTTSN PKNLRSSKYC TDVAKMIQAP VFHVNADDIE 

       430        440        450        460        470        480 
ASIFAIQLAL KFKKKFKKDV FIDLVCYRRH GHNEVDDPFV TQPIMYKKIH NHPTIGQIYS 

       490        500        510        520        530        540 
NLLISEKLIT SNDIEKIIEK YTTKLVQGKN VLSQERNITF QNGNKNFFIK KQKENTQLNF 

       550        560        570        580        590        600 
LNIKDLLYSI NTIPNSIEVH NRVKKIYQER IGMADGQILL DWGTAELLAY ATILKEGISC 

       610        620        630        640        650        660 
RLSGEDISRG TFFHRHAFIH DQNNGSIYVP LQNIEKNQGK FEIWDSVLSE EAVLAFEYGY 

       670        680        690        700        710        720 
SLFPSNNLTI WEAQFGDFAN GAQVVIDQFI SSSEQKWNQK SNLVLFLPHG YEGQGPEHSS 

       730        740        750        760        770        780 
ARLERFLQLC AENNIQVCIP TVSSQIFHLL RRQIFSNVYK PLIVLTPKSL LRNNVARSSL 

       790        800        810        820        830        840 
EVLVNENFKN VINEIDKNQK EVKRIIFCSG KIYYDLLEYR NKCDINNVLL IRIEQLYPFP 

       850        860        870        880        890        900 
KDEILTILKS YSYVQDFIWC QEEPHNQGAW FYIKDLLSTL LPLNSHLNYV SRPSAASPAA 

       910        920 
GHILIHRKEQ EKLINNAFNF KIA

Q8K9N3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools