ID   AMHR2_MOUSE             Reviewed;         568 AA.
AC   Q8K592; Q0VDQ4;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Anti-Muellerian hormone type-2 receptor;
DE            EC=2.7.11.30;
DE   AltName: Full=Anti-Muellerian hormone type II receptor;
DE            Short=AMH type II receptor;
DE   AltName: Full=MIS type II receptor;
DE   AltName: Full=MISRII;
DE            Short=MRII;
DE   Flags: Precursor;
GN   Name=Amhr2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97445109; PubMed=9299437; DOI=10.1006/bbrc.1997.7224;
RA   Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G.,
RA   Jenkins N.A., Cate R.L., Behringer R.R.;
RT   "Sequence, genomic organization, and chromosomal location of the mouse
RT   Muellerian-inhibiting substance type II receptor gene.";
RL   Biochem. Biophys. Res. Commun. 237:741-746(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for anti-Muellerian hormone.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AF503863; AAM28608.1; -; mRNA.
DR   EMBL; BC119571; AAI19572.1; -; mRNA.
DR   PIR; JC5629; JC5629.
DR   RefSeq; NP_653130.1; -.
DR   UniGene; Mm.60331; -.
DR   HSSP; P36897; 1IAS.
DR   PhosphoSite; Q8K592; -.
DR   Ensembl; ENSMUSG00000023047; Mus musculus.
DR   GeneID; 110542; -.
DR   KEGG; mmu:110542; -.
DR   NMPDR; fig|10090.3.peg.30707; -.
DR   MGI; MGI:105062; Amhr2.
DR   HOVERGEN; Q8K592; -.
DR   NextBio; 364193; -.
DR   ArrayExpress; Q8K592; -.
DR   CleanEx; MM_AMHR2; -.
DR   GermOnline; ENSMUSG00000023047; Mus musculus.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0042562; F:hormone binding; ISS:UniProtKB.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0007548; P:sex differentiation; IMP:MGI.
DR   GO; GO:0007179; P:transforming growth factor beta receptor si...; TAS:MGI.
DR   InterPro; IPR017193; Anti-muellerian_hrmn_rcpt_II.
DR   InterPro; IPR015771; Anti-muellerian_hrmn_rcpt_II_C.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   PANTHER; PTHR23255:SF4; MIS_II_R; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PIRSF; PIRSF037392; AMHRII; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     15       Potential.
FT   CHAIN        16    568       Anti-Muellerian hormone type-2 receptor.
FT                                /FTId=PRO_0000260265.
FT   TOPO_DOM     16    147       Extracellular (Potential).
FT   TRANSMEM    148    168       Potential.
FT   TOPO_DOM    169    568       Cytoplasmic (Potential).
FT   DOMAIN      199    504       Protein kinase.
FT   NP_BIND     205    213       ATP (By similarity).
FT   ACT_SITE    329    329       Proton acceptor (By similarity).
FT   BINDING     226    226       ATP (By similarity).
FT   CARBOHYD     66     66       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    119    119       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    240    240       R -> G (in Ref. 1; AAM28608).
SQ   SEQUENCE   568 AA;  61195 MW;  AE89AA1727600E5E CRC64;
     MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC
     CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY
     SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD
     PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER
     AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM
     ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP
     PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC
     SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL
     EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS
     SCLLSVQQGP GSRSPDPVGD TVQVYVNE
//